[Methodological principles of the improvement of monitoring of the effects of man-made environmental factors on human health].

The paper reflects the basic principles in improving methods for studying the influence of environmental factors of anthropogenic origin on health. The basic principles of human toxicology, physiology, and genetics became a theoretical basis of this improvement. The main point of the paper lies in the variability of the body's adaptive capacities, which is caused by a complex of endogenous and exogenous factors. The adaptive reserve interpreted as a measure for the resistance of biological systems under specific environmental conditions is proposed as a universal index that reflects the whole complex of influences of these factors. The magnitude of a response to exposures at the populational level is shown to depend not only on their levels, but also on the average level of an adaptive reserve in the population, on the proportion of exposure-sensitive individuals.