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Chronic bronchitis and bronchiolitis with prominent globule leukocyte infiltration in a cat with .
Vet Pathol
March 2025
Azabu University, Kanagawa, Japan.
A 7-year-old mixed-breed cat presented with intermittent dry cough for 2 years. Histological examination of the lung biopsy revealed hyperplasia of bronchial and bronchiolar epithelium, and intraepithelial infiltration of globule leukocytes in many bronchi, bronchioles, and terminal bronchioles. Lymphoid aggregates cuffed airways, respiratory bronchioles, and alveolar ducts.
View Article and Find Full Text PDFDermal pathology in a Catahoula Leopard dog with Dermasparaxis Ehlers Danlos syndrome caused by a homozygous ADAMTS2 missense variant.
Top Companion Anim Med
March 2025
Department of Ophthalmology, Neurodegenerative Disease Research Laboratory, University of Missouri, Columbia, Missouri, 65211.
Dermatosparaxis is a subtype of Ehlers-Danlos syndrome (dEDS) that typically results in euthanasia of dogs in the first several months of life because of complications mostly related to extreme skin fragility. The goal of this report was to describe ultrastructural features of collagen fibrils from a dog with a milder form of dEDS. A skin biopsy sample was procured from a nearly 10-year-old Catahoula Leopard dog with dEDS associated with a previously published homozygous missense variant in ADAMTS2.
View Article and Find Full Text PDFCigarette smoke-induced epithelial cell ferroptosis promotes neutrophilic inflammation in patients with nasal polyps.
J Allergy Clin Immunol
March 2025
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Clinical Research Center for Nasal Inflammatory Diseases, Wuhan, China; Institute of Allergy and Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: Regulation of epithelial cell death has emerged as a key mechanism maintaining immune homeostasis in the airway. However, the mechanisms governing epithelial cell survival in nasal polyps (NPs) remains poorly understood.
Objective: To investigate the ferroptosis of nasal epithelial cell and its implications in the pathogenesis of NPs.
Salivary biomarkers for the molecular diagnosis of dementia with Lewy bodies.
J Alzheimers Dis
March 2025
Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
BackgroundDespite dementia with Lewy bodies (DLB) being the second most common form of neurodegenerative dementia, more than 80% of DLB cases are initially misdiagnosed. Alpha-synuclein (a-syn) and tau species have been detected in peripheral tissues and biological fluids of DLB patients and among different biological fluids, saliva represent an easely accessible and non-invasive source for biomarker detection.ObjectiveThis study aimed to investigate salivary a-syn and tau species as molecular disease biomarkers, assessing their potential in the diagnosis of DLB and in the differential diagnosis on respect to Alzheimer's disease (AD) and Parkinson's disease (PD).
View Article and Find Full Text PDFIsolation, characterization and virulence assessment of Type 1d CP bovine viral diarrhea virus originating from Inner Mongolia, China.
Front Vet Sci
February 2025
College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China.
In recent years, bovine viral diarrhea virus (BVDV) has been associated with increased respiratory and gastrointestinal diseases in cattle. Comprehensive monitoring and investigations into the virus's pathological features are crucial for developing effective prevention strategies. This study investigated BVDV prevalence and pathogenicity in farms undergoing elimination protocols, with a focus on characterizing a novel Cytopathic Bovine Viral Diarrhea Virus (CP-type BVDV) strain (HH839) isolated from a symptomatic calf in Hohhot, Inner Mongolia.
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