AI Article Synopsis
- The study aimed to evaluate how valaciclovir and its conversion to acyclovir behaves in the serum and breast milk of breastfeeding women after delivery.
- In the study, 5 women received valaciclovir for 7 days, with samples collected to measure drug levels in both serum and breast milk at various intervals.
- Results showed valaciclovir quickly turns into acyclovir, with peak levels found in breast milk being much lower than therapeutic doses typically given to infants, indicating a low risk for infants consuming breast milk from mothers on this medication.
Article Abstract
Objective: The purpose of this study was to determine the valaciclovir and acyclovir pharmacokinetic profiles in serum and breast milk after valaciclovir administration to women after delivery.
Study Design: Valaciclovir (500 mg twice daily for 7 days) was given to 5 women after delivery who were breast-feeding healthy term infants. Matched serum and breast milk samples were obtained after the initial dose, on day 5 and 24 hours after the drug was discontinued. Infant urine was obtained on day 5.
Results: Valaciclovir was rapidly converted to acyclovir. The peak serum acyclovir concentration occurred 3 hours before the peak breast milk concentration (2.7 microg/mL at 1 hour vs 4.2 microg/mL at 4 hours). The serum acyclovir elimination half-life was 2.3 hours. The ratio of breast milk to serum acyclovir concentration was highest 4 hours after the initial dose at 3.4 and reached steady state ratio at 1.85. The median infant urine acyclovir concentration at steady state was 0.74 microg/mL.
Conclusion: Valaciclovir is rapidly converted to acyclovir and concentrates in breast milk. However, the amount of acyclovir in breast milk after valaciclovir administration is considerably less (2%) than that used in therapeutic dosing of neonates.
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| http://dx.doi.org/10.1067/mob.2002.119183 | DOI Listing |
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