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Prevalence of Gastroesophageal Reflux in Interstitial Lung Diseases Clinic.
Cureus
December 2024
Pulmonology, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Background Interstitial lung diseases (ILDs) are a group of non-infectious diseases characterized by interstitial inflammation and fibrosis on histological examination. Gastroesophageal reflux disease (GERD) is common in this patient population, but whether there is a causal or coincidental relationship is not yet clear. It still remains unsettled how to diagnose GERD, and the role of different treatment modalities for GERD, in these lung disorders.
View Article and Find Full Text PDFArtificial stone silicosis: a UK case series.
Thorax
September 2024
National Heart and Lung Institute, Imperial College, London, UK.
Silicosis due to artificial stone (AS) has emerged over the last decade as an increasing global issue. We report the first eight UK cases. All were men; median age was 34 years (range 27-56) and median stone dust exposure was 12.
View Article and Find Full Text PDFDetection of serum CC16 by a rapid and ultrasensitive magnetic chemiluminescence immunoassay for lung disease diagnosis.
Clin Chem Lab Med
January 2025
Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), 12550 College of Laboratory Medicine, Chongqing Medical University, Chongqing, China.
Objectives: It has been reported that serum Clara cell secreted protein 16 (CC16) is a potential biomarker for lung injury diseases, but currently, there is no other method that is faster, more accurate, or more sensitive being applied in clinical practice apart from ELISA. The current study was designed to established a magnetic nanoparticles chemiluminescence immunoassay (MNPs-CLIA) for highly sensitive automated detection of serum Clara cell secretory protein 16 (CC16), and validated its diagnostic performance for lung disease.
Methods: The study included the expression of CC16 recombinant protein, the preparation and screening of its monoclonal antibody (MAb), as well as the construction, optimization and analytical evaluation of the MNPs-CLIA method.
Elevated Levels of the Cancer Marker Neuron-Specific Enolase in a Patient With Coexisting Silicosis and Sarcoidosis.
Cureus
May 2024
Health Informatics, Kyoto University, Graduate School of Medicine, Kyoto, JPN.
In a periodical medical checkup, a 39-year-old Mongolian underground miner was diagnosed with silicosis based on chest radiography, computed tomography (CT), and work history. Chest radiography showed diffuse bilateral rounded nodules in both lung fields, with upper lobe dominance and large opacities in the right upper zone. Chest CT presented conglomerated massive changes in the right upper lobe and the coalescence of small nodules in the left upper lung.
View Article and Find Full Text PDFOccupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study.
Occup Environ Med
July 2024
Department of Occupational Medicine, Danish Ramazzini Centre, Aarhus University Hospital, Aarhus, Denmark.
Article Synopsis
- Respirable crystalline silica is linked to not only silicosis but also idiopathic interstitial pneumonias and pulmonary sarcoidosis, highlighting the health risks for exposed workers.
- The study followed the Danish working population from 1977 to 2015, estimating silica exposure using a job exposure matrix and identifying cases through a national patient register.
- Results indicated a significant increase in disease incidence with higher silica exposure, suggesting a need for more comprehensive analysis to confirm these findings and address potential misclassification issues.
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