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Exercise alleviates hematopoietic stem cell injury following radiation via the carnosine/Slc15a2-p53 axis.
Cell Commun Signal
December 2024
State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing, 400038, China.
Article Synopsis
- Ionizing radiation (IR) can damage hematopoietic stem cells (HSCs), causing myelosuppression, but the protective effects of moderate exercise against this damage are still being studied.
- This research shows that long-term moderate exercise helps protect HSCs from IR injury by generating carnosine in skeletal muscles, which supports HSC function and reduces bone marrow damage.
- Carnosine, transported to HSCs via a specific mechanism, inhibits the activity of the p53 protein, leading to enhanced HSC survival and proliferation after IR exposure—suggesting that exercise or carnosine supplementation could be beneficial strategies against IR-related damage.
Taurine ameliorates radiation-induced oxidative stress in bone marrow mesenchymal stromal cells and promotes osteogenesis.
Free Radic Biol Med
November 2024
Department of Oral Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, PR China. Electronic address:
Osteoradionecrosis of the jaw (ORNJ) is a severe complication following head and neck radiotherapy that significantly impacts the quality of life of patients. Currently, there is a lack of comprehensive understanding of the microenvironmental factors involved in ORNJ. In this study, we reveal the activation of taurine metabolism in irradiated mandibular stromal cells using scRNA-Seq and demonstrate a decrease in taurine levels in irradiated bone marrow mesenchymal stromal cells (BMSCs) through metabolomics.
View Article and Find Full Text PDFUnmet Needs in Spondyloarthritis: Imaging in Axial Spondyloarthritis.
J Rheumatol
December 2024
D. Poddubnyy, MD, Division of Rheumatology, Department of Medicine, University Health Network and University of Toronto, Toronto, Ontario, Canada, and Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité - Universitätsmedizin Berlin, Berlin, Germany.
Imaging biomarkers in axial spondyloarthritis (axSpA) are currently the most specific biomarkers for the diagnosis of this condition. Despite advances in imaging, from plain radiographs-which detect only damage-to magnetic resonance imaging (MRI)-which identifies disease activity and structural change-there are still many challenges that remain. Imaging in sacroiliitis is characterized by active and structural changes.
View Article and Find Full Text PDFCardiac radiation exposure and incident cancer: challenges and opportunities.
Eur Heart J Cardiovasc Imaging
November 2024
CORRIB Research Centre for Advanced Imaging and Core Laboratory, University of Galway, Galway, Ireland.
The use of radiological procedures has enormously advanced cardiology. People with heart disease are exposed to ionizing radiation. Exposure to ionizing radiation increases lifetime cancer risk with a dose-proportional hazard according to the linear no-threshold model adopted for radioprotection purposes.
View Article and Find Full Text PDFInterleukin-12 sustained release system promotes hematopoietic recovery after radiation injury.
MedComm (2020)
September 2024
Laboratory of Radiation Biology, Department of Blood Transfusion, Laboratory Medicine Center The Second Affiliated Hospital, Army Medical University Chongqing China.
Article Synopsis
- Hematopoietic stem cells are crucial for producing blood cells but are vulnerable to damage from ionizing radiation, which can lead to acute radiation syndrome (ARS) in victims.
- Researchers developed an injectable hydrogel combining Arg-Gly-Asp-alginate and Laponite that slowly releases interleukin-12, significantly improving survival rates and blood cell recovery in irradiated mice.
- The treatment enhances a specific signaling pathway that promotes the growth and repair of bone marrow cells, providing a potential new therapy for treating radiation-induced blood injury.
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