AI Article Synopsis
- The study aimed to measure netilmicin levels in tears after applying eye drops in 32 healthy volunteers.
- Participants were grouped and tears were collected at intervals of 5, 10, 20, and 60 minutes post-application, using a capillary suction method and analyzed with high-pressure liquid chromatography.
- Results indicated that netilmicin concentration in tears followed first-order kinetics and remained effective against common eye pathogens for over 120 minutes after administration.
Article Abstract
Purpose: To determine the concentration of netilmicin in tears after eye drop administration.
Methods: A clinical study was carried out on 32 healthy volunteers. Subjects were divided into four groups and underwent tear collection at 5, 10, 20, and 60-minutes after drug administration, respectively. Tear samples were collected through capillary suction from the inferior conjunctival "cul-de-sac" and analyzed by high-pressure liquid chromatography (HPLC).
Results: Netilmicin concentration in tears decreased after a first order kinetics, a best-fit curve was drawn and the minimum inhibitory concentration (MIC90) intersection for the most common ocular pathogens was calculated.
Conclusions: The extrapolation of the curve shows that the concentration of netilmicin on the ocular surface can be effective against microorganisms more than 120 minutes after eye drop instillation.
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| http://dx.doi.org/10.1097/00003226-200201000-00011 | DOI Listing |
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