We derive a formula for the distribution of the length T of the recombination interval containing a target gene and using N gametes in a region where R kilobases correspond to 1 cM. The formula can be used to calculate the number of meiotic events required to narrow a target gene down to a specific interval size and hence should be useful for planning positional cloning experiments. The predictions of this formula agree well with the results from a number of published experiments in Arabidopsis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461938 | PMC |
| http://dx.doi.org/10.1093/genetics/160.1.353 | DOI Listing |
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