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Comprehensive Molecular Evaluation of HNF-1 Alpha, miR-27a, and miR-146 Gene Variants and Their Link with Predisposition and Progression in Type 2 Diabetes Patients.
J Pers Med
August 2023
Department of Statistics, University of Tabuk, Tabuk 47512, Saudi Arabia.
Background: Type 2 diabetes (T2D) is a metabolic condition induced by insulin resistance and pancreatic beta cell dysfunction. MicroRNAs (miRNAs) have biological significance because they regulate processes such as the molecular signaling pathways involved in the pathophysiology of diabetes mellitus. The hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is a transcription factor found in hepatocytes and the pancreas.
View Article and Find Full Text PDFHepatocellular adenoma subtyping by qualitative MRI features and machine learning algorithm of integrated qualitative and quantitative features: a proof-of-concept study.
Clin Radiol
September 2023
Joint Department of Medical Imaging, University Health Network, Sinai Health System, University of Toronto, 585 University Ave., Toronto, ON, M5G 2N2, Canada. Electronic address:
Article Synopsis
- - The study aimed to assess the effectiveness of using qualitative MRI features and machine learning (ML) techniques to categorize different subtypes of hepatocellular adenoma (HCA), using histopathology as the standard for validation.
- - Researchers analyzed 39 HCAs from 36 patients by having two radiologists classify HCA subtypes using MRI features and compared this with ML algorithms, achieving notable diagnostic accuracies for specific subtypes like HNF-1-alpha mutated HCA (87% accuracy).
- - Results showed that while qualitative MRI features combined with ML offered high accuracy for HCA subtyping, quantitative features were particularly useful in diagnosing HNF-1-alpha mutated HCA, suggesting these methods are helpful in improving patient management.
Hereditary Persistence of Alpha-Fetoprotein in Chronic Liver Disease-Confusing Genes!
J Clin Exp Hepatol
December 2020
Institute of Liver Disease and Transplantation, Dr. Rela Institute and Medical Centre, Bharath Institute of Higher Education and Research, Chennai, Tamilnadu, India.
Alpha-fetoprotein (AFP) is a glycoprotein secreted by the embryonic liver and is expressed in tumours with high mitotic index such as hepatocellular carcinoma (HCC) and germ cell tumours. Detection of elevated AFP is strongly associated with underlying HCC or occasionally germ cell tumour. Modest elevation of AFP can be observed in patients with chronic viral hepatitis particularly with active replication.
View Article and Find Full Text PDFCase Report: Hepatic Adenoma in a Child With a Congenital Extrahepatic Portosystemic Shunt.
Front Pediatr
August 2020
Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.
Congenital extrahepatic portosystemic shunts (CEPS), previously also described as Abernethy malformations, are rare malformations in which the extrahepatic portal system directly communicates with the vena cava inferior, thereby bypassing the liver. A hypoplastic portal vein (PV) exists in most cases. CEPS have been associated with the development of liver nodules, ranging from mostly focal nodular hyperplasia (FNH) to hepatic adenoma (HA) and even hepatocellular carcinoma (HCC).
View Article and Find Full Text PDFHNF-1 binding point mutation of the AFP gene promotes cirrhosis in post-menopausal women.
Int J Biol Markers
March 2020
Department of Pathology, 1st Affiliated Hospital, Fujian Medical University, Fuzhou, China.
Objective: α-fetoprotein (AFP) expression is activated during the embryonic stage or hepatocellular carcinogenesis, so it is presumed that AFP is a key endogenous molecule to promote cell proliferation or differentiation. We carried out gene screening in an unknown family with hyper-alpha-fetoproteinemia and some sporadic menopausal women, and discussed the relationship between AFP expression and liver cirrhosis.
Methods: Peripheral blood samples from family members, patients with malignant liver tumors, and normal controls were collected.
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