Disseminated intravascular clotting (DIC) is a well-recognized complication of malignancy. Prostatic cancer can produce chronic DIC as well as acute severe DIC. Treatment of DIC are general supportive measures including heparin, transfusion of blood, platelets and clotting factors, but the most important aspect is correction of underlying malignant diseases i.e. cancer of the prostate gland. For metastatic prostatic cancer presenting with an emergency oncologic condition, the treatment of choice is surgical orchiectomy, but surgery may not be possible in the presence of severe DIC. Ketoconazole and Flutamide are drugs with different mechanisms for hormonal manipulation of this cancer. Due to severe DIC, we combined both drugs trying to put maximum therapeutic effect on this life threatening profound DIC patient.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A comparison of disseminated intravascular coagulation scoring systems and their performance to predict mortality in sepsis patients: A systematic review and meta-analysis.
PLoS One
January 2025
Department of Internal Medicine, Jimma University, Jimma, Ethiopia.
Background: Disseminated intravascular coagulation (DIC) is a common complication in sepsis patients which exacerbates patient outcomes. The prevalence and outcomes of DIC in sepsis is wide-ranging and highly depends on the severity of the disease and diagnostic approaches utilized. Varied diagnostic criteria of DIC have been developed and their performance in diagnosis and prognosis is not consistent.
View Article and Find Full Text PDFDissolved Inorganic Carbon Evolution of Sediment Porewater in the Huixian Wetland, Southwest China.
Ground Water
January 2025
Institute of Karst Geology, Chinese Academy of Geological Sciences, Guilin, 541004, China.
Wetlands, as crucial terrestrial carbon reservoirs, have recently suffered severe degradation due to intense human activities. Lacustrine sediments serve as vital indicators for understanding wetland environmental changes. In the current paper, porewater samples were extracted from lacustrine sediment in three boreholes with a depth of ~75 cm in the Huixian karst wetland, southwest China, to study the chemical and dissolved inorganic carbon (DIC) evolution under anthropogenic influence.
View Article and Find Full Text PDFOcean acidification and its regulating factors in the East China Sea off the Yangtze River estuary.
Mar Environ Res
January 2025
Key Laboratory of Marine Ecosystem Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou, 310012, China; State Key Laboratory of Satellite Ocean Environment Dynamics, Second Institute of Oceanography, Ministry of Natural Resources, Hangzhou, 310012, China.
This study examines the seasonal variations in carbonate system parameters in the East China Sea (ECS) off the Yangtze River estuary (YRE) and analyzes the contributions of anthropogenic CO₂ and eutrophication to acidification. Carbonate parameters data were collected during summer 2019 and combined winter 2011. During winter, acidification is primarily driven by rising atmospheric CO₂, with minimal impact from biological processes.
View Article and Find Full Text PDFInhibition of NETs prevents doxorubicin-induced cardiotoxicity by attenuating IL-18-IFN-γ-Cx43 axis induced cardiac conduction abnormalities.
Int Immunopharmacol
January 2025
Department of Pharmacy, Shenzhen Children's Hospital, Shenzhen, Guangzhou, China. Electronic address:
Doxorubicin-induced cardiotoxicity (DIC) is one of the most severe side effects of doxorubicin, yet the underlying mechanisms remain incompletely understood. Our results showed that Neutrophil extracellular traps (NETs) accumulated in plasma and cardiac tissue after doxorubicin treatment. The inhibition of NETs formation by Pad4 gene ablation significantly attenuated doxorubicin-induced arrhythmia, prolonged survival time and reduced the levels of Troponin T (cTnT) and creatine kinase MB (CK-MB) in mice.
View Article and Find Full Text PDFClinical practice guidelines for management of disseminated intravascular coagulation in Japan 2024. Part 3: solid cancers and vascular abnormalities.
Int J Hematol
January 2025
Associated Department With Mie Graduate School of Medicine, Mie Prefectural General Medical Center, Yokkaichi, Japan.
This study discusses disseminated intravascular coagulation (DIC) associated with solid cancers and various vascular abnormalities, both of which generally exhibit chronic DIC patterns. Solid cancers are among the most significant underlying diseases that induce DIC. However, the severity, bleeding tendency, and progression of DIC vary considerably depending on the type and stage of the cancer, making generalization difficult.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!