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Retinal dysfunction in APOE4 knock-in mouse model of Alzheimer's disease.
Alzheimers Dement
January 2025
Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Introduction: Late-onset Alzheimer's Disease (LOAD) is the predominant form of Alzheimer's disease (AD), and apolipoprotein E (APOE) ε4 is a strong genetic risk factor for LOAD. As an integral part of the central nervous system, the retina displays a variety of abnormalities in LOAD. Our study is focused on age-dependent retinal impairments in humanized APOE4-knock-in (KI) and APOE3-KI mice developed by the Model Organism Development and Evaluation for Late-Onset Alzheimer's Disease (MODEL-AD) consortium.
View Article and Find Full Text PDFPM and hospitalizations through the emergency department in people with disabilities: a nationwide case-crossover study in South Korea.
Lancet Reg Health West Pac
December 2024
School of Biomedical Convergence Engineering, College of Information and Biomedical Engineering, Pusan National University, Yangsan, South Korea.
Background: Little is known about the impact of PM on people with disabilities. We aimed to explore the association between PM and hospitalization via the emergency department (ED admission) among people with disabilities, together with the attributable ED admission cases and costs.
Methods: We applied a time-stratified case-crossover design adjusting ozone, holiday, and temperature using seven years (2015-2021) of claim-based data on ED admissions from the Korean National Health Insurance Database.
A Unique Presentation of Atypical Hemolytic Uremic Syndrome With Unilateral Blindness and Ischemic Stroke: A Case Report.
Cureus
November 2024
Department of Medicine, Dr. Baba Saheb Ambedkar Medical College and Hospital, New Delhi, IND.
This report describes a rare presentation of atypical hemolytic uremic syndrome with multi-system involvement, including unilateral blindness and stroke. Only a few cases of atypical hemolytic uremic syndrome with unilateral blindness as a presentation have been reported and all have been attributed to central retinal artery obstruction (CRAO). This is the first described case to our knowledge of atypical hemolytic uremic syndrome presenting with unilateral blindness, which was caused by grade four hypertensive retinopathy.
View Article and Find Full Text PDFSudden vision loss in pregnancy: Wernicke's encephalopathy in a patient with hyperemesis gravidarum.
BMJ Case Rep
December 2024
Ophthalmology, Kasturba Medical College Mangalore, Mangalore, Karnataka, India.
Wernicke's encephalopathy, the acute phase of Wernicke-Korsakoff syndrome, is characterised as a triad of altered mental status, ocular signs and ataxia. Our patient presented with hyperemesis gravidarum, which is a rare aetiology of Wernicke's encephalopathy. The patient did not have any oculomotor abnormalities, which are more common and classically described in Wernicke's triad.
View Article and Find Full Text PDFAdvanced bioengineering strategies broaden the therapeutic landscape for corneal failure.
Front Bioeng Biotechnol
November 2024
Institute for Neurosciences of Montpellier, INSERM, University of Montpellier, Montpellier, France.
The cornea acts as the eye foremost protective layer and is essential for its focusing power. Corneal blindness may arise from physical trauma or conditions like dystrophies, keratitis, keratoconus, or ulceration. While conventional treatments involve medical therapies and donor allografts-sometimes supplemented with keratoprostheses-these options are not suitable for all corneal defects.
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