The effects of subinhibitory concentrations of silver sulphadiazine (AgSD) on exoprotein production in Staphylococcus aureus strains T1, T4, RN4282 and RN 4282agr were studied. AgSD markedly increased levels of toxic shock syndrome toxin (TSST)-1 in strains T4 and RN4282. This effect was independent of agr and AgSD restored TSST-1 production to the wild-type level in RN 4282agr. AgSD had no effect on enterotoxin A or coagulase activity in strains T1 or T4. Strain T4 produced enterotoxin C at high levels and no effect was observed with AgSD. AgSD repressed metalloprotease production in strain T4 but the overall protease activity remained the same. No change in proteolytic activities was seen in strainT1 with AgSD. Molecular mechanisms for these observations are discussed.
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