Tetanic stimulation of the tooth pulp produced long lasting increases in potentials released by stimulation of the tooth pulp with single stimuli in the sensomotor cortex of rabbits. Stimulation with 200 impulses/sec for 5 sec produced changes of irritability that are demonstrable for 10-50 min depending on the intensity of stimulation. The lower rate limit for producing such changes is 25 impulses/sec. At a rate of 200 impulses/sec, a stimulation time of 25 msec was necessary to produce these changes. The postexcitatory depression occuring after single stimuli within 10-40 msec was increased by tetanic stimulation, whereas facilitation observed 5 msec after single stimuli was unaffected.
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J Cachexia Sarcopenia Muscle
February 2025
Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Canada.
Background: Duchenne muscular dystrophy (DMD) is a devastating disease characterized by progressive muscle wasting that leads to diminished lifespan. In addition to the inherent weakness of dystrophin-deficient muscle, the dysfunction of resident muscle stem cells (MuSC) significantly contributes to disease progression.
Methods: Using the mdx mouse model of DMD, we performed an in-depth characterization of disease progression and MuSC function in dystrophin-deficient skeletal muscle using immunohistology, isometric force measurements, transcriptomic analysis and transplantation assays.
J Physiol
December 2024
Department of Neuroscience and Pharmacology, The University of Iowa, Iowa City, IA, USA.
cAMP signalling is critical for memory consolidation and certain forms of long-term potentiation (LTP). Phosphodiesterases (PDEs), enzymes that degrade the second messengers cAMP and cGMP, are highly conserved during evolution and represent a unique set of drug targets, given the involvement of these enzymes in several pathophysiological states including brain disorders. The PDE4 family of cAMP-selective PDEs exert regulatory roles in memory and synaptic plasticity, but the specific roles of distinct PDE4 isoforms in these processes are poorly understood.
View Article and Find Full Text PDFClin Neurophysiol
December 2024
Nara Medical University, Department of Anesthesiology, Kashihara, Japan. Electronic address:
Adv Healthc Mater
November 2024
Translational Tissue Engineering Center, School of Medicine, Johns Hopkins University, Baltimore, MD, 21231, USA.
Neuromuscular deficits compound the loss of contractile tissue in volumetric muscle loss (VML). Two avenues for promoting recovery are neuromuscular junction (NMJ)-promoting substrates (e.g.
View Article and Find Full Text PDFGlobal Spine J
November 2024
Department of Orthopaedic Surgery, Nara Medical University, Kashihara, Japan.
Study Design: Prospective within-subjects study.
Objectives: Although motor-evoked potential (MEP) amplitude can reportedly be increased by tetanic stimulation of the peripheral nerves before transcranial electrical stimulation (TES), no reports have described on whether tetanic transcranial stimulation augments the wave amplitudes of spinal cord-evoked potentials (Tc-SCEP). The primary purpose of this study was to investigate whether tetanic stimulation induces waveform amplification of Tc-SCEP.
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