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Remifentanil-Propofol-Ketamine- Based Total Intravenous Anesthesia with Spontaneous Breathing for Adult Rigid Bronchoscopy.
J Clin Med
January 2025
Department of Thoracic Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Via Alvaro del Portillo, 200, 00128 Rome, Italy.
Rigid bronchoscopy (RB) is the gold standard for managing central airway obstruction (CAO), a life-threatening condition caused by both malignant and benign etiologies. Anesthetic management is challenging as it requires balancing deep sedation with maintaining spontaneous breathing to avoid airway collapse. There is no consensus on the optimal anesthetic approach, with options including general anesthesia with neuromuscular blockers or spontaneous assisted ventilation (SAV).
View Article and Find Full Text PDFAutoantibodies in COVID-19: implications for disease severity and clinical outcomes.
Front Immunol
January 2025
Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Few pathogens have historically been subjected to as intense scientific and clinical scrutiny as SARS-CoV-2. The genetic, immunological, and environmental factors influencing disease severity and post-infection clinical outcomes, known as correlates of immunity, remain largely undefined. Clinical outcomes of SARS-CoV-2 infection vary widely, ranging from asymptomatic cases to those with life-threatening COVID-19 symptoms.
View Article and Find Full Text PDFGLP-1 and the Neurobiology of Eating Control: Recent Advances.
Endocrinology
January 2025
Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6DE, UK.
Obesity is now considered a chronic relapsing progressive disease, associated with increased all-cause mortality that scales with body weight, affecting more than 1 billion people worldwide. Excess body fat is strongly associated with excess energy intake, and most successful anti-obesity medications (AOMs) counter this positive energy balance through the suppression of eating to drive weight loss. Historically, AOMs have been characterized by modest weight loss and side effects which are compliance-limiting, and in some cases life-threatening.
View Article and Find Full Text PDFZBP1-driven cell death in severe influenza.
Trends Microbiol
January 2025
Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA. Electronic address:
Influenza A virus (IAV) infections can cause life-threatening illness in humans. The severity of disease is directly linked to virus replication in the alveoli of the lower respiratory tract. In particular, the lytic death of infected alveolar epithelial cells (AECs) is a major driver of influenza severity.
View Article and Find Full Text PDFDiscovery of anti-Ebola virus multi-target inhibitors from traditional Chinese medicine database using molecular screening, biophysical investigation, and binding free energy calculations.
J Infect Public Health
February 2025
Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar. Electronic address:
Article Synopsis
- Ebola virus (EBOV) is a highly deadly RNA virus that currently lacks effective treatments or vaccines, necessitating the urgent need for new therapeutic solutions.
- In this study, researchers used in silico methods to evaluate natural products from traditional Chinese medicine against four critical EBOV proteins, employing molecular docking to assess their potential effectiveness.
- The findings identified eight promising compounds with strong inhibitory effects on EBOV proteins, indicating their potential as antiviral agents due to their favorable interaction with protein residues and acceptable pharmacokinetic profiles.
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