Dominant-negative Rho, Rac, and Cdc42 facilitate the invasion process of Vibrio parahaemolyticus into Caco-2 cells.

Infect Immun

Department of Bacterial Infections. Department of Bacterial Toxinology, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.

Published: February 2002

AI Article Synopsis

  • The study investigated how Vibrio parahaemolyticus invades host cells using a specific assay.
  • Researchers used cells with a dominant negative version of small GTPases from the Rho family to see how they affect invasion.
  • The findings indicate that the way V. parahaemolyticus invades cells is different from the invasion methods of other bacteria.

Article Abstract

To clarify the invasive process of Vibrio parahaemolyticus, an invasion assay was performed using cells expressing dominant negative small GTPases of the Rho family. This assay showed that the dominant negative host phenotype facilitates bacterial invasion, suggesting that the mechanism of V. parahaemolyticus invasion differs from that reported for other invasive bacteria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127689PMC
http://dx.doi.org/10.1128/IAI.70.2.970-973.2002DOI Listing

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