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Toll-like receptor-immobilized carbon paste electrodes with plasma functionalized amine termination: Towards real-time electrochemical based triaging of gram-negative bacteria.
Biosens Bioelectron
December 2023
Department of Electrical Engineering, Indian Institute of Technology Hyderabad, 502284, India. Electronic address:
Chronic wounds caused due to bacterial biofilms are detrimental to a patient, and an immediate diagnosis of these bacteria can aid in an effective treatment, which is still an unmet clinical need. An instant and accurate identification of bacterial type could be made by utilizing the Toll-Like Receptors (TLRs) combined with Myeloid Differentiation factor 2 (MD-2). Given this, we have developed an electrochemical sensing platform to identify the gram-negative (gram-ve) bacteria using TLR4/MD-2 complex.
View Article and Find Full Text PDFBenchmarking of Machine Learning classifiers on plasma proteomic for COVID-19 severity prediction through interpretable artificial intelligence.
Artif Intell Med
March 2023
Institute of Applied Biosciences, Centre for Research & Technology Hellas, Thermi, Thessaloniki, Greece.
The SARS-CoV-2 pandemic highlighted the need for software tools that could facilitate patient triage regarding potential disease severity or even death. In this article, an ensemble of Machine Learning (ML) algorithms is evaluated in terms of predicting the severity of their condition using plasma proteomics and clinical data as input. An overview of AI-based technical developments to support COVID-19 patient management is presented outlining the landscape of relevant technical developments.
View Article and Find Full Text PDFThe role of the MAD2-TLR4-MyD88 axis in paclitaxel resistance in ovarian cancer.
PLoS One
February 2021
Department of Histopathology, Trinity College Dublin, Dublin, Ireland.
Despite the use of front-line anticancer drugs such as paclitaxel for ovarian cancer treatment, mortality rates have remained almost unchanged for the past three decades and the majority of patients will develop recurrent chemoresistant disease which remains largely untreatable. Overcoming chemoresistance or preventing its onset in the first instance remains one of the major challenges for ovarian cancer research. In this study, we demonstrate a key link between senescence and inflammation and how this complex network involving the biomarkers MAD2, TLR4 and MyD88 drives paclitaxel resistance in ovarian cancer.
View Article and Find Full Text PDFCellular and Kaposi's sarcoma-associated herpes virus microRNAs in sepsis and surgical trauma.
Cell Death Dis
December 2014
1] Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA [2] The Center for RNA Interference and Non-coding RNAs, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Article Synopsis
- Survival rates in septic shock patients decrease by 7.6% for every hour antibiotics are delayed, highlighting the urgency of timely treatment.
- This study investigates the role of specific cellular and viral miRNAs as biomarkers for diagnosing and triaging sepsis by analyzing their expression in different patient groups.
- Findings show distinct levels of certain miRNAs linked to sepsis, particularly KSHV miRNAs, are influenced by patient ethnicity and post-surgical recovery, suggesting their potential for future diagnostic and therapeutic applications.
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