AI Article Synopsis
- Hrk is a pro-apoptotic BH3-only protein that regulates cell death and triggers apoptosis in nerve tissue, particularly in retinal ganglion cells (RGCs).
- After optic nerve transection in adult rats, Hrk gene expression was found to increase 12 hours post-injury and remained elevated for a week.
- In situ hybridization revealed that Hrk was specifically expressed in a subset of RGCs that were injured, indicating its role in promoting cell death in these cells after trauma.
Article Abstract
Hrk, a regulator of cell death, belongs to the family of pro-apoptotic BH3-only proteins and is known to induce apoptosis in nerve tissue. We examined Hrk gene expression to clarify the role of BH3-only proteins in apoptosis of retinal ganglion cells (RGCs) after optic nerve transection in the adult rat. Reverse transcription-polymerase chain reaction showed that Hrk was up-regulated in retina from 12 h after axotomy, and continued to be elevated for 1 week. In situ hybridization histochemistry revealed that Hrk was expressed in a sub-population of axotomized RGCs. These results suggest that Hrk is involved in the induction of apoptosis in RGCs after optic nerve transection.
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| http://dx.doi.org/10.1016/s0304-3940(01)02487-9 | DOI Listing |
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