Transplantation
Manchester Institute of Nephrology and Transplantation, Manchester Royal Infirmary, Oxford Road, Manchester, UK M13 9WL.
Published: January 2002
We report the case of an ethnic Asian patient who attended the renal transplant follow-up clinic complaining of pain in the right great toe. He had undergone transplantation nine months earlier and was maintained on triple immunosuppression. Initially, a clinical diagnosis of gout was made and the patient treated with analgesia. Two weeks later he remained symptomatic and developed a discharging sinus on his toe. A plain X-ray revealed a lytic lesion with minimal periosteal reaction. Aspiration of his first right metatarsal phalangeal joint was performed and fungal hyphae were observed in the fluid. Subsequently, despite surgical debridement and treatment with Itraconozaole amputation of the toe was required. Microbiological analysis revealed the organism to be Madurella grisea,which was resistant to both Itraconazole and Amphotericin B. He has remained well since amputation. We believe this to be the first case of Madurella infection to be described in a transplant patient.
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http://dx.doi.org/10.1097/00007890-200201150-00029 | DOI Listing |
Int J Mol Sci
January 2025
Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.
Eumycetoma, a chronic fungal infection caused by , is a neglected tropical disease characterized by tumor-like growths that can lead to permanent disability and deformities if untreated. Predominantly affecting regions in Africa, South America, and Asia, it imposes significant physical, social, and economic burdens. Current treatments, including antifungal drugs like itraconazole, often show variable efficacy, with severe cases necessitating surgical intervention or amputation.
View Article and Find Full Text PDFJ Glob Health
January 2025
Department of Health Education, Faculty of Public and Environmental Health, University of Khartoum, Khartoum, Sudan.
Background: Mycetoma is a chronic granulomatous disease affecting the skin, subcutaneous tissues, and bones, particularly in tropical and subtropical regions. Sudan, especially its Eastern Sinnar locality, experiences a significant burden due to environmental conditions and limited access to healthcare, while the population's lack of awareness and understanding often leads to delays in diagnosis and treatment.
Methods: We conducted a descriptive cross-sectional, community-based study in Eastern Sinnar, Sudan, to investigate the prevalence, risk factors, and awareness of mycetoma among local residents.
Med Mycol Case Rep
March 2025
Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
A 49-year old female, known to have had an asymptomatic pulmonary cavity since 2015, presented in 2023 with hemoptysis. Radiology showed a mass suspected to be an aspergilloma. Due to persistent hemoptysis, lobectomy was performed.
View Article and Find Full Text PDFExpert Rev Anti Infect Ther
January 2025
Dermatology Department, Brighton General Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
Introduction: Mycetoma is a chronic granulomatous infection, common throughout tropical regions, and is considered a neglected disease that mostly affects impoverished populations. Mycetoma is divided into eumycetoma, caused by fungi, and actinomycetoma, caused by filamentous bacteria. Clinical presentation is distinctive, and making the diagnosis is usually not difficult; however, access to safe and effective treatments is a major challenge.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
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End the Neglect Initiative, Research and Development, Research office, 11111 Khartoum, Sudan.
Snakebite envenomation is a neglected tropical disease that affects millions of people in sub-Saharan Africa, including Sudan. The severity of snakebite envenomation ranges from mild to severe, and can even lead to death. Sudan has a high burden of snakebite envenomation, with an estimated 12 632 cases and a mortality rate of 2.
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