AI Article Synopsis
- Neural stem cells can be sourced from both adult and embryonic nervous systems, but distinguishing them is challenging due to undefined markers.
- Researchers have identified various endothelial and hematopoietic receptors on embryonic human neural stem cells, which are partly retained as these cells differentiate.
- This finding implies that neural stem cells possess a broader capability than assumed, enabling them to respond to diverse environmental signals and potentially influencing stem cell fate conversion.
Article Abstract
Neural stem cells can be derived from the adult/embryonic nervous system as well as from more primitive embryonic stem cells but, because of the lack of specific markers, only their differentiated progeny can be characterized. We here report the presence of several endothelial and hematopoietic receptors (at protein and mRNA level) on the surface of embryonic human neural stem cells, which are partially maintained during differentiation. This suggests that neural stem cells have a greater potential than previously thought, which involves the ability to respond to different and so far unconsidered environmental signals and may be responsible for the recently discovered process of stem cell-fate conversion.
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| http://dx.doi.org/10.1016/s0006-8993(01)03291-7 | DOI Listing |
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