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An International, Multidisciplinary Consensus Set of Patient-Centered Outcome Measures for Substance-Related and Addictive Disorders.
J Clin Med
April 2024
National Drug and Alcohol Research Centre, UNSW, Sydney 2052, Australia.
In 1990, the United States' Institute of Medicine promoted the principles of outcomes monitoring in the alcohol and other drugs treatment field to improve the evidence synthesis and quality of research. While various national outcome measures have been developed and employed, no global consensus on standard measurement has been agreed for addiction. It is thus timely to build an international consensus.
View Article and Find Full Text PDFPharmacotherapy in Managing Alcohol-Use Disorder.
Gastroenterology
May 2024
Department of Metabolism, Digestion, and Reproduction, St Mary's Hospital Campus, Imperial College London, Paddington, London, United Kingdom.
The effect of liquid-liquid extraction on metabolite detection and analysis using NMR spectroscopy in human synovial fluid.
J Pharm Biomed Anal
March 2023
Department of Orthopaedics & Trauma, Imperial College Healthcare NHS Trust, Mary's Hospital, Praed Street, Paddington, London W2 1NY, UK; Department of Surgery and Cancer, Imperial College London, South Kensington, London SW7 2AZ, UK.
The evaluation of joint disease using synovial fluid is an emerging field of metabolic profiling. The analysis is challenged by multiple macromolecules which can obscure the small molecule chemistry. The use of protein precipitation and extraction has been evaluated previously, but not in synovial fluid.
View Article and Find Full Text PDFGenital injuries and allegation of digital vaginal penetration - A retrospective examination of forensic case notes.
J Forensic Leg Med
May 2021
The Havens, Kings College Hospital NHS Foundation Trust, London, UK.
Objective: To determine the prevalence of genital injuries following alleged sexual assault by digital penetration of the vagina in the absence of penile penetration of the vagina or anus in women age 16 and over; and to compare with the prevalence of genital injuries following alleged sexual assault by penile vaginal penetration in the absence of penile penetration of the anus or digital penetration of the vagina and/or anus.
Population: 1428 adults and children attending a forensic medical examination between September 2017 and January 2020 at the Haven sexual assault referral center situated in Paddington, London, UK.
Design: Retrospective review of forensic notes.
Accumulated exposure to unemployment is related to impaired glucose metabolism in middle-aged men: A follow-up of the Northern Finland Birth Cohort 1966.
Prim Care Diabetes
August 2017
Center for Life Course Health Research, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland. Electronic address:
Aims: We explored whether registered unemployment is associated with impaired glucose metabolism in general population.
Methods: Based on Northern Finland Birth Cohort 1966 at 46 years, we analyzed the oral glucose tolerance tests of 1970 men and 2544 women in relation to their preceding three-year employment records in three categories of unemployment exposure: no (employed), low (≤1-year) and high exposure (>1-year).
Results: Among men, pre-diabetes was found in 19.
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