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In-situ Forming Multipolymeric Glucose-Responsive Hydrogels.
Chem Asian J
December 2024
Departments of Chemistry, Bioscience and Biomedical Engineering, Indian Institute of Technology-Bhilai, Durg, Chhattisgarh, 491002, India.
Stimuli-responsive hydrogels (HGs) have shown promise for smart drug delivery applications. Specifically, glucose-responsive HGs having phenylboronic acid (PBA) functional groups are extensively pursued for insulin delivery in hyperglycemia. Current polymeric glucose-responsive HGs are cumbersome to fabricate and show a limited insulin release profile.
View Article and Find Full Text PDFRecent Insights into Glucose-Responsive Concanavalin A-Based Smart Hydrogels for Controlled Insulin Delivery.
Gels
April 2024
"Petru Poni" Institute of Macromolecular Chemistry, 41-A Grigore Ghica Voda Alley, 700487 Iasi, Romania.
Many efforts are continuously undertaken to develop glucose-sensitive biomaterials able of controlling glucose levels in the body and self-regulating insulin delivery. Hydrogels that swell or shrink as a function of the environmental free glucose content are suitable systems for monitoring blood glucose, delivering insulin doses adapted to the glucose concentration. In this context, the development of sensors based on reversible binding to glucose molecules represents a continuous challenge.
View Article and Find Full Text PDFMultiplexed Complementary Signal Transmission for a Self-Regulating Artificial Nervous System.
Adv Sci (Weinh)
January 2023
Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul, 03722, Republic of Korea.
Article Synopsis
- * The paper introduces an artificial nervous system that uses multiplexed complementary signals for effective self-regulation.
- * A practical application of this system is demonstrated through a feedback-based blood glucose control mechanism that regulates glucose and insulin levels using sensors and specialized circuits.
Carbon Dots Embedded Hybrid Microgel with Phenylboronic Acid as Monomer for Fluorescent Glucose Sensing and Glucose-Triggered Insulin Release at Physiological pH.
Nanomaterials (Basel)
September 2022
Henan International Joint Laboratory of Medicinal Plants Utilization, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
A multifunctional and biocompatible hybrid microgel (poly(VPBA-AAm)-CD) using N, S-doped carbon dots (CDs) and ethylene glycol dimethacrylate (EGDMA) as cross-linking agents, and 4-vinylbenzene boronic acid (VPBA) and acrylamide (AAm) as monomers, was designed in this work. This microgel can be easily prepared by a simple one-pot radical dispersion polymerization of the reactants using a rationally designed hydrogen-bonded complex method. The hybrid microgels were spherical particles with a smooth surface and an average particle size of 234 ± 8 nm.
View Article and Find Full Text PDFProximal Disruption of Brain Energy Supply Raises Systemic Blood Glucose: A Systematic Review.
Front Neurosci
June 2021
Medical Clinic 1, Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany.
This work joins a series that methodically tests the predictions of the Selfish-Brain theory. The theory postulates a vital ability of the mammalian brain, namely to give priority to its own energy metabolism. The brain behaves "selfishly" in this respect.
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