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Cells-of-Origin of Breast Cancer and Intertumoral Heterogeneity.
Adv Exp Med Biol
January 2025
Cancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Wurundjeri Country, Melbourne, Australia.
Both intrinsic and extrinsic mechanisms underpin the profound intertumoral heterogeneity in breast cancer. Increasing evidence suggests that the intrinsic characteristics of breast epithelial precursor cells may influence tumour phenotype. These "cells-of-origin" of cancer preside in normal breast tissue and are uniquely susceptible to mutagenesis upon exposure to distinct oncogenic stimuli.
View Article and Find Full Text PDFMatrix Metalloproteinase-9 is associated with tumor microenvironment remodeling of bladder cancer.
Biol Direct
January 2025
Department of Urology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233030, China.
Tumor microenvironment (TME) takes an essential part in the bladder cancer progression, which is associated with intercellular cross-talk between stroma cells and cancer. We aimed use bioinformatics tools to analyze tumor microenvironment remodeling in bladder cancer. CIBERSORT and ESTIMATE are bioinformatics tools based on deconvolution for calculating proportions of tumor-infiltrating immune cells and stromal components in TME.
View Article and Find Full Text PDFInterferon-ε loss is elusive 9p21 link to immune-cold tumors, resistant to immune-checkpoint therapy and endogenous CXCL9/10 induction.
J Thorac Oncol
December 2024
Moores Cancer Center, University of California San Diego, La Jolla, CA 92037, USA; Department of Medicine, University of California San Diego, La Jolla, CA 92037, USA; Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Introduction: Copy-number (CN) loss of chromosome 9p, or parts thereof, impair immune response and confer ICT resistance by direct elimination of immune-regulatory genes on this arm, notably IFNγ genes at 9p24.1, and type-I interferon (IFN-I) genes at 9p21.3.
View Article and Find Full Text PDFDriver mutation landscape of acute myeloid leukemia provides insights for neoantigen-based immunotherapy.
Cancer Lett
December 2024
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Acute myeloid leukemia (AML) has lagged in benefiting from immunotherapies, primarily due to the scarcity of actionable AML-specific antigens. Driver mutations represent promising immunogenic targets, but a comprehensive characterization of the AML neoantigen landscape and their impact on patient outcomes and the AML immune microenvironment remain unclear. Herein, we conducted matched DNA and RNA sequencing on 304 AML patients and extensively integrated data from additional ∼2500 AML cases, identifying 49 driver genes, notably characterized by a significant proportion of insertions and deletions (indels).
View Article and Find Full Text PDFNickel-based cocatalysts on Titanium-doped Hematite empower direct photoelectrochemical valorisation of 5-Hydroxymethylfurfural.
ChemSusChem
December 2024
University of Bologna, Physics and Astronomy, v.le Berti-Pichat 6/2, 40127, Bologna, ITALY.
The photoelectrochemical oxidation of 5-hydroxymethylfurfural (HMF), a biomass-derived intermediate, to 2,5-furandicarboxylic acid (FDCA), a key building block for industrial applications, is a well-studied anodic reaction. This photoelectrochemical (PEC) conversion typically requires an electron mediator, such as TEMPO, regardless of the semiconductor used. Various electrocatalysts can also perform this reaction electrochemically, without additional organic species in the electrolyte.
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