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Biomarkers.
Alzheimers Dement
December 2024
Adult Neurodevelopment and Geriatric Psychiatry Division, CAMH, Toronto, ON, Canada.
Background: Previous literature has identified slowing of resting state electroencephalography (EEG) rhythm and abnormal cortical excitation in Alzheimer's Dementia (AD). However, the relationship between these two divergent functional abnormalities and cognitive symptoms of AD are not well understood.
Method: Resting state EEG signal was recorded in participants with AD and HCs for 5 minutes with eyes closed.
Repetitive TMS (rTMS) is a powerful neuroscientific tool with the potential to noninvasively identify brain-behavior relationships in humans. Early work suggested that certain rTMS protocols (e.g.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Background: Cortical excitability is elevated in Alzheimer's disease (AD). Transcranial magnetic stimulation-evoked responses on electromyography (EMG) and electroencephalography (EEG) have captured this increased excitability in motor brain regions. However, it is not yet known if increased excitability is also present in the parietal lobe or the extent to which excitability is related to cognition.
View Article and Find Full Text PDFThe effects of transcranial direct current stimulation on global cognition in patients with Alzheimer's disease: An update meta-analysis.
J Alzheimers Dis
January 2025
School of Clinical Medicine, Qilu Medical University, Zibo, Shandong, China.
Background: Alzheimer's disease (AD) is a neurodegenerative disease. At present, there are currently no drugs that can cure AD.
Objective: A number of empirical studies have shown that transcranial direct current stimulation (tDCS) may be used to treat cognitive abnormalities in patients with AD.
Targeting VMPFC-amygdala circuit with TMS in substance use disorder: A mechanistic framework.
Addict Biol
January 2025
Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, USA.
The ventromedial prefrontal cortex (VMPFC), located along the medial aspect of the frontal area, plays a critical role in regulating arousal/emotions. Its intricate connections with subcortical structures, including the striatum and amygdala, highlight the VMPFC's importance in the neurocircuitry of addiction. Due to these features, the VMPFC is considered a promising target for transcranial magnetic stimulation (TMS) in substance use disorders (SUD).
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