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Psoriasis increases the risk of Sjögren's syndrome: evidence from a propensity score-matched cohort study and transcriptomic analysis.
BMC Med
January 2025
Department of Rheumatology and Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Despite the well-documented immune dysregulation in both psoriasis and Sjögren's syndrome (SS), the specific link between these two autoimmune diseases has not been extensively explored. The present study aims to investigate the impact of psoriasis on the risk of SS.
Methods: A retrospective cohort study using TriNetX data compared SS development in patients with psoriasis and controls using propensity score matching, Kaplan-Meier curves, and Cox models.
Comparative evaluation of several toric intraocular lens calculators for predicting postoperative refractive astigmatism in cataract surgery: a real-world study.
BMC Ophthalmol
January 2025
Department of Ophthalmology, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing, China.
Background: This study aims to comprehensively evaluate the predictive accuracy of six widely used toric intraocular lens (IOL) calculators in eyes undergoing cataract surgery with toric IOL implantation.
Methods: This retrospective study reviewed 53 eyes of 53 patients that underwent cataract extraction with toric IOL implantation using Zeiss 709 M. Six toric IOL calculators were evaluated: Barrett toric calculator (with predicted PCA, measured PCA, and TK), Kane formula (predicted PCA), and EVO 2.
3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study.
BMC Cancer
January 2025
Department of Radiology, Zhuhai Clinical Medical College of Jinan University (Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology), No. 79 Kangning Road, Zhuhai, 519000, Guangdong Province, China.
Background: Besides tumorous information, synergistic liver parenchyma assessments may provide additional insights into the prognosis of hepatocellular carcinoma (HCC). This study aimed to investigate whether 3D synergistic tumor-liver analysis could improve the prediction accuracy for HCC prognosis.
Methods: A total of 422 HCC patients from six centers were included.
Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease.
J Transl Med
January 2025
Department of Endocrine Medicine, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201306, Chin, China.
Background And Objective: Mitochondria are crucial to the function of renal tubular cells, and their dynamic perturbation in many aspects is an important mechanism of diabetic kidney disease (DKD). Single-nucleus RNA sequencing (snRNA-seq) technology is a high-throughput sequencing analysis technique for RNA at the level of a single cell nucleus. Here, our DKD mouse kidney single-cell RNA sequencing conveys a more comprehensive mitochondrial profile, which helps us further understand the therapeutic response of this unique organelle family to drugs.
View Article and Find Full Text PDFAssociation between stress hyperglycemia ratio and all-cause mortality in critically ill patients with sepsis: results from the MIMIC-IV database.
Eur J Med Res
January 2025
School of Medicine, Nankai University, Tianjin, 300071, China.
Background: This study aimed to explore the association between the stress hyperglycemia ratio (SHR) and short- and long-term outcomes in critically ill patients with sepsis.
Methods: This retrospective observational cohort study was conducted using the Medical Information Mart for Intensive Care-IV (MIMIC-IV v2.2) database.
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