Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/0-306-46843-3_39 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Purinergic P2Y and P2Y receptors control enteric nervous system activity through neuro-glia-macrophage crosstalk.
Purinergic Signal
November 2024
Department of Physiology, Michigan State University, 567 Wilson Road, East Lansing, MI, 48824, USA.
Purines are important mediators of intercellular communication in the enteric nervous system (ENS) that participate in physiological gut functions and disease. Purinergic transmission is prominent in mechanisms of crosstalk between enteric neurons and glia where enteric glia exhibit high responsiveness to adenosine diphosphate (ADP) through P2Y receptors and neurons to adenosine triphosphate (ATP) through P2X receptors. Despite functional data suggesting that enteric glia are the primary site of P2Y expression in the ENS, gene sequencing suggests that P2Y expression is more enriched in neurons than glia.
View Article and Find Full Text PDFPurinergic-associated immune responses in neurodegenerative diseases.
Prog Neurobiol
December 2024
Univ. Bordeaux, CNRS, IMN, UMR 5293, Bordeaux F-33000, France. Electronic address:
The chronic activation of immune cells can participate in the development of pathological conditions such as neurodegenerative diseases including Alzheimer's disease (AD), Multiple Sclerosis (MS), Parkinson's disease (PD), Huntington's disease (HD) and Amyotrophic Lateral Sclerosis (ALS). In recent years, compelling evidence indicates that purinergic signaling plays a key role in neuro-immune cell functions. The extracellular release of adenosine 5'-triphosphate (ATP), and its breakdown products (ADP and adenosine) provide the versatile basis for complex purinergic signaling through the activation of several families of receptors.
View Article and Find Full Text PDFMechanosensitive release of ATP in the urinary bladder mucosa.
Purinergic Signal
November 2024
Department of Physiology and Cell Biology, School of Medicine, University of Nevada Reno, Reno, NV, 89557, USA.
The urinary bladder mucosa (urothelium and suburothelium/lamina propria) functions as a barrier between the content of the urine and the underlying bladder tissue. The bladder mucosa is also a mechanosensitive tissue that releases signaling molecules that affect functions of cells in the bladder wall interconnecting the mucosa with the detrusor muscle and the CNS. Adenosine 5'-triphosphate (ATP) is a primary mechanotransduction signal that is released from cells in the bladder mucosa in response to bladder wall distention and activates cell membrane-localized P2X and P2Y purine receptors on urothelial cells, sensory and efferent neurons, interstitial cells, and detrusor smooth muscle cells.
View Article and Find Full Text PDFExploring P2X7 receptor antagonism as a therapeutic target for neuroprotection in an hiPSC motor neuron model.
Stem Cells Transl Med
December 2024
Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, United States.
ATP is present in negligible concentrations in the interstitium of healthy tissues but accumulates to significantly higher concentrations in an inflammatory microenvironment. ATP binds to 2 categories of purine receptors on the surface of cells, the ionotropic P2X receptors and metabotropic P2Y receptors. Included in the family of ionotropic purine receptors is P2X7 (P2X7R), a non-specific cation channel with unique functional and structural properties that suggest it has distinct roles in pathological conditions marked by increased extracellular ATP.
View Article and Find Full Text PDFPurines and purinergic receptors in primary tumors of the central nervous system.
Purinergic Signal
October 2024
Department of Graduate Studies in Biomedical Sciences, Federal University of Fronteira Sul, Rodovia SC 484 - Km 02, Fronteira Sul, Chapecó, SC, CEP 89815-899, Brazil.
Article Synopsis
- Purine nucleotides and nucleosides are crucial in various diseases, especially in tumor growth, with ATP promoting tumor receptor activation and adenosine acting as an immunosuppressant.
- This study explores how ATP and its metabolites, along with specific receptors, impact primary central nervous system tumors and their progression.
- The results suggest that the purinergic system's role in tumors can vary, acting as either a promoter or inhibitor of tumor growth, depending on receptor density and the surrounding environment, highlighting ATP's significance in cancer development.*
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!