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The role of 5'-deoxy-5'-methyl thioadenosine phosphorylase in cardiac adenosine breakdown and adenine production.
Adv Exp Med Biol
February 2002
Department of Biochemistry, Medical University of Gdansk, Poland.
Undifferentiated neural hybrid NG108-15 cells plated on laminin-coated, polylysine-treated plastic Petri dishes in minimal serum-free media formed long neurites within 1-4 h post-plating. Morphologic features and pharmacologic responses of these 'rapid onset' neurites were strikingly similar to those of neuronal growth cones. Cycloheximide (1-10 micrograms/ml) and forskolin (10(-7) to 10(-6) M) accelerated the initial formation of laminin-stimulated neurites, but did not cause rapid onset neurites to emerge upon Petri dishes coated with polylysine alone.
View Article and Find Full Text PDFEffects of 5'deoxy-5'-methylthioadenosine on the metabolism of S-adenosyl methionine.
Biochem Biophys Res Commun
July 1983
The treatment of transformed rat cells with micromolar amounts of 5'deoxy 5'methyl thioadenosine induces rapid effects on the rate of methylation of DNA concomitantly with alterations of intracellular pools of S-adenosyl methionine and S-adenosyl homocysteine. Pulse chase labelling experiments indicate that 5'deoxy 5'methylthioadenosine does not inhibit the degradation of S-adenosyl homocysteine but inhibits the consumption of S-adenosyl methionine. In vitro transmethylation assays performed with heterologous DNA show that low doses of the thioethernucleoside do not significantly affect the DNA methyltransferase activity of cellular extracts.
View Article and Find Full Text PDFThe biological activities of several previously synthesized [J. A. Montgomery et al.
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