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Influence of Multidrug Resistance 1 Gene Variants on Response to Intravenous Methylprednisolone Pulse in Systemic Lupus Erythematosus Patients: Preliminary Results.
Curr Rheumatol Rev
January 2025
Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Egypt.
Introduction/objectives: Genetic variations could explain individual responses to drugs. This case-control study aimed to investigate the association between the multidrug resistance 1 (MDR1) gene exonic single nucleotide variants (SNVs), rs1128503/C1236T and rs1045642/C3435T, and the response to intravenous methylprednisolone in Egyptian patients with active systemic lupus erythematosus (SLE).
Method: Real-time polymerase chain reaction was used.
Effect of MDR1 C3435T and CYP2C19 genetic polymorphisms on the outcome of Helicobacter pylori eradication treatment in children with gastritis and peptic ulcer, Vietnam.
BMC Pediatr
July 2024
Department of Pediatrics, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Background: Helicobacter pylori eradication therapy based on antimicrobial susceptibility in Vietnamese children currently get low efficiency. There are causes of treatment failure, among host genetic factors namely MDR1 C3435T and CYP2C19 affect the absorption and metabolism of proton pump inhibitors - a crucial component of eradication therapy. The study aimed to investigate the effect of MDR1 C3435T and CYP2C19 genetic polymorphisms on the cure rate.
View Article and Find Full Text PDFThe impact of matched and mismatched donor-recipient genotypes for MDR1 polymorphisms (G2677TA, C1236T and C3435T) on the outcomes of patients after allogeneic haematopoietic stem cell transplantation.
Br J Haematol
August 2024
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
In this study, we investigated whether matched and mismatched multidrug resistance gene (MDR1) genotypes (G2677TA, C1236T and C3435T) were associated with prognosis in patients after allogeneic haematopoietic stem cell transplantation (allo-HSCT). One hundred patients after transplantation and their donors were enrolled. Matched MDR1 G2677TA donor-recipient was associated with an increased risk of non-relapse mortality (NRM) (29.
View Article and Find Full Text PDFThe association between abcb1 gene polymorphism and clopidogrel response variability in stroke ischemic: a cross sectional study.
BMC Neurol
June 2024
Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Article Synopsis
- - The study investigates how variations in the ABCB1 gene (which affects clopidogrel absorption) influence the response to clopidogrel in ischemic stroke patients, assessing the impact of two specific polymorphisms: C3435T and C1236T.
- - In a sample of 124 patients, the results show that about 12.9% were non-responsive to clopidogrel, while 41.9% faced a higher risk of bleeding, particularly those with the C1236T homozygote wildtype genotype, which increased bleeding risk by 3.76 times.
- - The research found that the most prevalent genotype for ABCB1 C3435T was heterozygote
Association between the MDR1 rs1045642 polymorphism and breast cancer risk: An updated meta‑analysis.
Oncol Lett
April 2024
Department of Breast Surgery Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430016, P.R. China.
Multidrug resistance 1 (MDR1) is a transmembrane transporter on the cell membrane. As an ATP-dependent efflux pump, MDR1 is mainly responsible for the adsorption, distribution, metabolism, excretion and transportation of anticancer drugs to cancer cells. Mutations of the MDR1 gene may be associated with the incidence of cancer.
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