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Reichert's membrane - A continuing enigma for developmental biologists.
Dev Biol
January 2025
Developmental Biology & Cancer Department, UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address:
Reichert's membrane (RM) is a basement membrane of gigantic proportions that surrounds the mammalian embryo following implantation. It is part of the parietal yolk sac, which originates from the wall of the preimplantation blastocyst. RM persists from implantation to birth in rodents and analogous structures occur in other mammals, including primates.
View Article and Find Full Text PDFArrhythmias Following Patent Foramen Ovale Closure: An Unsolved Enigma.
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First Department of Cardiology, Hippokration Hospital, Athens Medical School, National and Kapodistrian University of Athens, Vas. Sofias 114, 11527 Athens, Greece.
Patent foramen ovale (PFO) closure has proven to be an effective method of reducing the risk of recurrent stroke in patients with embolic stroke of unknown origin (ESUS). One of the most recognized post-procedural complications is the de novo occurrence of supraventricular arrhythmias, mainly atrial fibrillation, in the first three months following PFO closure. Earlier studies reported the incidence to be around 3.
View Article and Find Full Text PDFThe organization of the cell's cytoskeletal filaments is coordinated through a complex symphony of signaling cascades originating from internal and external cues. Two major actin regulatory pathways are signal transduction through Rho family GTPases and growth and proliferation signaling through the Hippo pathway. These two pathways act to define the actin cytoskeleton, controlling foundational cellular attributes such as morphology and polarity.
View Article and Find Full Text PDFThe Enigma That Is ROHHAD Syndrome: Challenges and Future Strategies.
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October 2024
Bristol Royal Hospital for Children, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol BS2 8BJ, UK.
Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation (ROHHAD) is a rare syndrome presenting in early childhood associated with a high risk of mortality between 50 and 60%. It is characterised by rapid, early onset of obesity between 1.5-7 years, along with central hypoventilation and hypothalamic dysfunction, such as central hypothyroidism, hyperprolactinemia, disorders of sodium and water balance, growth hormone deficiency, adrenocortical insufficiency, or disorders of puberty and features of autonomic dysregulation.
View Article and Find Full Text PDFUnveiling the enigma: Pulmonary hypertension in marginal zone non-Hodgkin's lymphoma: A singular case illuminating an obscure nexus.
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Staten Island University Hospital, Northwell Health, Staten Island, NY, USA.
Article Synopsis
- The presence of pulmonary hypertension in patients with non-Hodgkin's lymphoma indicates a worse prognosis, highlighting the urgent need for early diagnosis and customized treatment approaches.
- Traditional treatments for pulmonary hypertension may not be effective due to the cancer's impact, making it crucial to start chemotherapy quickly.
- This case study reviews a specific instance of pulmonary hypertension in marginal zone lymphoma and discusses broader challenges in diagnosing and treating this condition in non-Hodgkin's lymphoma patients.
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