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Tingling, Numbness, and Underlying Malignancy: A Case Report of Glioblastoma Multiforme.
Cureus
December 2024
General Medicine, Dartford and Gravesham NHS Trust, Dartford, GBR.
Glioblastoma multiforme (GBM) is a World Health Organisation (WHO) grade IV glioma originating from astrocytes. It is the most common malignant primary tumour of the brain and central nervous system (CNS) and is associated with fast progression and violent local spread, with a median overall survival of approximately 15 months after diagnosis. Due to its late and varied presentation, it is often diagnosed only after it has grown considerably.
View Article and Find Full Text PDFInhibitory Effect of PRMT5/MTA Inhibitor on MTAP-Deficient Glioma May Be Influenced by Surrounding Normal Cells.
Cancer Med
December 2024
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong, People's Republic of China.
Background: Methylthioadenosine phosphorylase (MTAP) and protein arginine methyltransferase 5 (PRMT5) are considered to be a synthetic lethal pair of targets, due to the fact that deletion of MTAP leads to massive production of methylthioadenosine (MTA) decreasing the activity of PRMT5. In vitro and in vivo experiments have demonstrated that MRTX1719, a small molecule that selectively binds PRMT5/MTA complex, significantly inhibits the proliferation of MTAP-deficient tumors and has a weak toxic effect on normal cells. However, it has been reported that MTAP-deleted tumors did not significantly accumulate MTA in vivo due to metabolism of MTA by MTAP-expressing stroma, which might lead to a diminished anti-cancer effect of MRTX1719.
View Article and Find Full Text PDFA big data analysis algorithm for massive sensor medical images.
PeerJ Comput Sci
November 2024
Research Center, Future University in Egypt, New Cairo, Egypt.
Article Synopsis
- Big data analytics is revolutionizing clinical decision-making by utilizing vast healthcare data to create evidence-based solutions, but it raises significant privacy and security concerns, especially regarding sensitive medical images stored in the cloud.
- The proposed project aims to enhance patient care through a machine learning-based anomaly detection system for medical images, addressing current limitations in existing detection methods that struggle with resource consumption and real-time performance.
- The research focuses on improving data processing techniques, including feature selection and handling missing values, employing advanced algorithms like recursive feature elimination and dynamic principal component analysis for more effective anomaly detection.
Infective endocarditis causing recurrent cerebral infarction, cerebral hemorrhage and septic meningitis: A case report.
Medicine (Baltimore)
November 2024
Department of Neurology, Weifang People's Hospital, Weifang, Shandong, China.
Rationale: We reported a rare case of recurrent cerebral infarction, intracerebral hemorrhage, and purulent meningitis, culminating in the diagnosis of a young patient with infective endocarditis who had been treated in 3 hospitals for a long course of illness for 8 months prior to diagnosis. It aims to enhance clinicians' understanding of the neurological complications caused by infective endocarditis.
Patient Concerns: A 25-year-old male, student, was hospitalized for an 8-hour history of speech impairment and drooling with dysphagia.
Angioembolization for hemostasis in craniofacial fractures had a higher probability of delayed traumatic intracerebral hemorrhage.
Am J Emerg Med
January 2025
Department of Trauma and Emergency Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung Medical College & University, Taoyuan City, Taiwan. Electronic address:
Introduction: While angioembolization is occasionally required for craniofacial fracture patients who experience massive maxillofacial hemorrhage, complications such as headache, temporal-facial pain, soft tissue necrosis, and embolic material migration leading to stroke or blindness can arise. Few studies have explored delayed or progressive intracerebral hemorrhage (ICH) following angioembolization for craniofacial fractures.
Methods: A retrospective review of craniofacial fracture patients from January 1, 2015, to December 31, 2022 at our institution was conducted.
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