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Graph contrastive learning of subcellular-resolution spatial transcriptomics improves cell type annotation and reveals critical molecular pathways.
Brief Bioinform
November 2024
School of Artificial Intelligence, Jilin University, Qianjin Street 2699, 130010 Changchun, China.
Imaging-based spatial transcriptomics (iST), such as MERFISH, CosMx SMI, and Xenium, quantify gene expression level across cells in space, but more importantly, they directly reveal the subcellular distribution of RNA transcripts at the single-molecule resolution. The subcellular localization of RNA molecules plays a crucial role in the compartmentalization-dependent regulation of genes within individual cells. Understanding the intracellular spatial distribution of RNA for a particular cell type thus not only improves the characterization of cell identity but also is of paramount importance in elucidating unique subcellular regulatory mechanisms specific to the cell type.
View Article and Find Full Text PDFIndividual vocal identity may be obscured following colony assembly in captive black-capped chickadees.
Behav Processes
January 2025
Department of Psychology, University of Alberta-, 11455 Saskatchewan Drive, Edmonton, AB, Canada, T6G 2E9; Neuroscience and Mental Health Institute, University of Alberta-, 2-132 Li Ka Shing Centre for Health Research Innovation, Edmonton, Alberta, Canada, T6G 2E1. Electronic address:
Black-capped chickadee (Poecile atricapillus) vocalisations remain plastic throughout their lifespans. Although fledglings employ vocal plasticity to refine their vocalisations through the use of tutor mimicry, adults employ vocal plasticity to create unique population dialects. Vocal convergence is one mechanism by which flockmates' vocalisations become increasingly similar to each other and distinct from the calls of other flocks.
View Article and Find Full Text PDFTranslation and cultural adaption of MacLeod Clark professional identity scale among Chinese therapy students.
PLoS One
January 2025
Faculty of Life Sciences & Medicine, King's College London, London, United Kingdom.
Background: Fostering a strong professional identity (PI) enhances career fulfillment. In China, therapy education is undergoing development, integrating both Western and traditional health concepts, causing inconsistent PI among therapy students. To date, no validated tools exist to measure and monitor PI of Chinese therapy students.
View Article and Find Full Text PDFUsing Social Media to Promote Life Skills Among Adolescents: A Debate on Opportunities, Challenges, and Implications for Health and Education.
J Prev (2022)
January 2025
Department of Health and Prevention, Institute of Psychology, University of Greifswald, Robert-Blum-Str. 13, 17489, Greifswald, Germany.
The digitalization of society increasingly blurs boundaries between analog and digital worlds, offering opportunities such as telemedicine and global connectivity through digital platforms. However, it also presents risks, including cyberbullying, addiction potential, harmful content, misinformation, and privacy concerns from data breaches and surveillance technologies. Social media, with its global reach, amplifies both opportunities for positive engagement and the responsibility to navigate largely unregulated content.
View Article and Find Full Text PDFComparative transcriptomic rhythms in the mouse and human prefrontal cortex.
Front Neurosci
January 2025
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Introduction: Alterations in multiple subregions of the human prefrontal cortex (PFC) have been heavily implicated in psychiatric diseases. Moreover, emerging evidence suggests that circadian rhythms in gene expression are present across the brain, including in the PFC, and that these rhythms are altered in disease. However, investigation into the potential circadian mechanisms underlying these diseases in animal models must contend with the fact that the human PFC is highly evolved and specialized relative to that of rodents.
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