Objective: Explores the feasibility of guiding bone tissue regeneration by frozen homologous periosteum.
Methods: Rabbit's cranial periosteum was taken and refrigerated. In thirty-one white Japanese big ear rabbits, defects of the mandible were created. Defect at one side was covered with the membrane, another side not. The rabbits were sacrificed on four, eight, twelve, sixteen weeks. Specimens were examined by naked eye, X-ray, and histology.
Results: The frozen homologous periosteummet the requirement of guiding bone tissue regeneration There was no rejection, and could be kept 8 for 12 weeks in the body. It had the favorable efficacy of obstructing the fiber tissue from filling into bone defects and had an efficacy of guiding bone tissue regeneration.
Conclusions: Frozen homologous periosteum is a perfect guiding bone tissue regeneration membrane.
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