Background And Study Aims: Though many gastric varices are treated endoscopically with n-butyl-2-cyanoacrylate, its behavior in varices is not known precisely.
Materials And Methods: We created a varix model. A volume of 0.7 ml or 1.4 ml of 71.4 % n-butyl-2-cyanoacrylate, a tissue adhesive, was injected into vinyl tubes of 0.4, 0.6, 0.9, and 1.2 cm in diameter, which were filled with still blood or flowing blood. The tissue adhesive was also injected into the inferior vena cava or femoral vein of dogs.
Results: N-butyl-2-cyanoacrylate was similarly polymerized in the vinyl tubes and the animal veins. A volume of 0.7 ml of the tissue adhesive could block all tubes up to 0.6 cm in diameter. A double quantity of the tissue adhesive could block tubes 0.9 and 1.2 cm in diameter, with flow velocities up to 10 cm/s and up to 5 cm/s, respectively. Some polymer masses were fragmented.
Conclusions: One rapid shot of the tissue adhesive can block a vessel 0.6 cm or less in diameter with fast flow velocity, and a vessel up to 1.2 cm in diameter with slow flow velocity. Fast blood flows in a larger diameter vessel and slow injection of the tissue adhesive may result in fragmentation. This model of the varix was useful for assessing the effect of tissue adhesive used to treat gastric varices.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-2002-19384 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Lithium Bond-Mediated Molecular Cascade Hydrogel for Injury-Free and Repositionable Adhesive Bioelectronic Interfaces.
Adv Mater
March 2025
Key Laboratory of Ocean Energy Utilization and Energy Conservation of Ministry of Education, School of energy and power engineering, Dalian University of Technology, Dalian, 116024, P. R. China.
Flexible bioelectronic interfaces with adhesive properties are essential for advancing modern medicine and human-machine interactions. However, achieving both stable adhesion and non-damaging detachment remains a significant challenge. In this study, a lithium bond-mediated molecular cascade hydrogel (LMCH) for bioelectronic interfaces is designed, which facilitates robust adhesion at the tissue level and permits atraumatic detachment for repositioning as required.
View Article and Find Full Text PDFInjectable photosensitive bone cement enhancing angiogenesis and osteogenic differentiation for the treatment of bone nonunion.
APL Bioeng
March 2025
Institutes of Health Central Plain, The Third Affiliated Hospital of Xinxiang Medical University, Clinical Medical Center of Tissue Engineering and Regeneration, Xinxiang Medical University, Xinxiang 453003, People's Republic of China.
Nonunion fractures present a significant clinical challenge because of their complex microenvironment, which includes poor vascularization, insufficient osteogenesis, infection, and separation of fracture ends. The current clinical treatments have certain limitations. Inspired by this phenomenon, sandcastle worms secrete adhesive proteins that bind sand grains, shell fragments, and mineral particles, thereby constructing their "castles.
View Article and Find Full Text PDFAdhesive Hemostatic Flake Particulates Composed of Calcium Alginate-Starch-Polyacrylamide/Poly(Acrylic Acid) Ionic Networks.
Polymers (Basel)
February 2025
Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi 39177, Gyeongbuk, Republic of Korea.
Hemostatic particles have specific advantages when applied to narrow and complicated bleeding sites with convenient usage compared to other types of hemostatic agents such as fabrics, foams, and pastes. However, powdery hemostatic agents are easy to desorb from the bleeding surface due to blood flow, which causes a serious decrease in hemostasis function. Here, we introduce bioresorbable flake particulates composed of calcium alginate, starch and polyacrylamide/poly(acrylic acid) ionic networks as a wound adhesive hemostatic agent.
View Article and Find Full Text PDFA multifunctional semi-interpenetrating polymer network hydrogel dressing for wound healing.
Colloids Surf B Biointerfaces
March 2025
Key Lab. of Oral Diseases Research of Anhui Province, College & Hospital of Stomatology, Anhui Medical University, 81 Meishan Road, Hefei 230032, China; The institute of Oral Science, Department of Stomatology, Longgang Otorhinolaryngology Hospital of Shenzhen, Shenzhen 518172, China. Electronic address:
Hydrogels have exhibited significant application potential in the field of new wound dressings due to their unique physicochemical properties and biological functions. However, traditional hydrogels possess limitations regarding mechanical properties, adhesion, and the promotion of wound healing. Herein, a multifunctional polyvinyl alcohol-tannic acid/polyacrylamide-polydopamine (PVA-TA/PAM-PDA) hydrogels are developed.
View Article and Find Full Text PDFAn In Situ Curing, Shear-Responsive Biomaterial Designed for Durable Embolization of Microvasculature.
Adv Healthc Mater
March 2025
Arsenal Medical, Inc, 100 Beaver Street, Suite 302, Waltham, MA, 02453, USA.
Endovascular embolization is a minimally-invasive technique whereby blood vessels supplying pathological structures are selectively occluded with various embolic agents. In many scenarios, it is desirable for the embolic to distally penetrate to the level of the microvasculature, which maximizes devascularization. Existing agents exhibit inconsistent distal penetration and have other limitations including tendency for proximal reflux, patient pain during infusion, lack of fluoroscopic radiopacity, potential for catheter adhesion, susceptibility to recanalization, and other usability challenges.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!