AI Article Synopsis
- Cryopreservation allows for sperm preservation for fertilization, but frozen-thawed sperm experience structural and physiological changes that reduce their fertilizing potential.
- Factors contributing to these changes include the inherent fragility of sperm and the effects of semen dilution during the cryopreservation process.
- This work aims to review sperm cryopreservation, focusing on how sperm capacitation and elements like membrane cholesterol, reactive oxygen species, and seminal plasma influence sperm function post-freezing.
Article Abstract
Cryopreservation extends the availability of sperm for fertilization; however, the fertilizing potential of the frozen-thawed sperm is compromised because of alterations in the structure and physiology of the sperm cell. These alterations, characteristics of sperm capacitation, are present in the motile population and decrease sperm life-span, ability to interact with female tract, and fertilizing ability. The etiology of such alterations may represent a combination of factors, such as inherited fragility of the sperm cell to withstand the cryopreservation process and the semen dilution. Although the former is difficult to address, approaches that make-up for the dilution of seminal fluid may be sought. The aim of this work is to review aspects of sperm cryopreservation paralleled by events of capacitation and evaluate the possible roles of sperm membrane cholesterol, reactive oxygen species, and seminal plasma as mediators of cryopreservation effects on sperm function.
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| http://dx.doi.org/10.1016/s0093-691x(01)00674-4 | DOI Listing |
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