Objective: Our purpose was to find out if morphometric techniques can document long term changes in gastric antral atrophy after curing Helicobacter pylori infection with or without dietary supplementation with antioxidant micronutrients.
Methods: Study subjects were 132 adult volunteers from a Colombian region with high gastric cancer rates. Participants were randomly assigned to ascorbic acid, beta-carotene, and anti-H. pylori treatment, following a factorial design. Gastric biopsies were obtained at baseline and after 72 months of intervention. Atrophy was evaluated by a standard visual analog scale and by morphometry.
Results: Statistically significant changes in antral atrophy were detected with morphometric techniques after intervention in subjects who received anti-H. pylori treatment. A nonsignificant trend was also observed with visual scores. This effect was greater among those who were free of infection at the end of the trial. After accounting for the effect of anti-H. pylori treatment, no significant effect was noted for dietary supplementation with ascorbic acid and/or beta-carotene.
Conclusions: We conclude that gastric atrophy improves significantly after long term control of H. pylori infection. This effect can be demonstrated both by conventional histological grading and by morphometry.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1572-0241.2001.05326.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Autoimmune gastritis diagnosed due to recurrent gastric neuroendocrine tumor: a case report.
Front Med (Lausanne)
January 2025
Department of Gastroenterology, Dongyang People's Hospital, Dongyang, China.
As digestive endoscopy becomes more prevalent, an increasing number of autoimmune gastritis (AIG) cases have been diagnosed, which has contributed to a growing body of research on AIG. We report the case of a patient with AIG who was diagnosed due to receiving endoscopic surgery after discovering a gastric neuroendocrine tumor (GNET) during gastroscopy twice within 3 years. The patient was admitted to our hospital for endoscopic submucosal dissection (ESD) due to GNET recurrence discovered during gastroscopy.
View Article and Find Full Text PDFgastritis in Jordanian children: persistence versus resolution.
Prz Gastroenterol
November 2023
Pediatric Department, King Abdullah University Hospital, Irbid, Jordan.
Introduction: () is the most common cause of infectious gastritis. is an infection that is typically acquired during childhood.
Aim: This study aims to describe children with infection and compare the clinicopathological features of children with resolved and persistent infection.
Eradication of Helicobacter pylori by a potassium-competitive acid blocker alone?
Scand J Gastroenterol
December 2024
Department of clinical and molecular medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Aims: , the dominating cause of gastric cancer, most often infects children initiating inflammation in the antral part and spreads orally to the oxyntic mucosa. Traditionally, eradication of has been based upon a combination of antibiotics together with a proton pump inhibitor (PPI) to reduce gastric destruction of the antibiotics. Recently it has been shown that the more efficient inhibitors of acid secretion, the potassium-competitive acid blockers (PCABs) in combination with amoxicillin alone gave highly sufficient eradication.
View Article and Find Full Text PDFDifferent regimens for eradication of Helicobacter pylori infection in children: a randomized controlled trial.
Eur J Pediatr
November 2024
Pediatric Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Article Synopsis
- The study investigates the effectiveness and safety of various antibiotic therapies for eradicating Helicobacter pylori (H. pylori) infection in children, focusing on options like triple, sequential, hybrid, concomitant, and ciprofloxacin-based therapies.
- A randomized trial involving 200 children (ages 3-16) revealed that ciprofloxacin-based triple therapy achieved the highest eradication rate at 90%, compared to lower rates for other therapies, with no significant difference in adverse effects.
- The conclusion highlights that ciprofloxacin-based triple therapy is the most effective and safe option for treating H. pylori infection in children, while the other treatment options do not significantly outperform traditional triple therapy.*
Histopathological Features of Chronic Gastritis and its Association with Infection.
Korean J Gastroenterol
October 2024
Hind Institute of Medical Sciences, Barabanki, UP, India.
Background/aims: A () infection is the most common cause of chronic gastritis (CG), with approximately 50% of the world's population infected. Long-term infection increases the risk of progression to gastric cancer. This study evaluated the histopathological changes in CG using the Updated Sydney System (USS) to estimate the prevalence and correlation of gastritis with other histological variables.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!