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Oncologists' views on ototoxicity monitoring in head and neck cancer patients: A South Indian qualitative study.
PLoS One
January 2025
Department of ENT, Head and Neck Surgery, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India.
Article Synopsis
- The study investigates oncologists' awareness of ototoxicity and monitoring practices in head and neck cancer patients in South India using semi-structured interviews.
- All oncologists recognized the ototoxic effects of treatments but considered the resulting hearing loss minor and did not prioritize counseling on this issue.
- Despite awareness of ototoxicity monitoring programs, none had implemented them, indicating a need for improved education and advocacy among oncologists about the importance of these programs.
Hearing Impairment in Oral Submucous Fibrosis: A Systematic Review.
Ear Nose Throat J
January 2025
Department of Dentistry, Zydus Medical College and Hospital, Dahod, Gujarat, India.
Article Synopsis
- Oral submucous fibrosis (OSMF) is a serious condition associated with areca nut chewing, linked to dental health and possibly hearing impairment, prompting a need for investigation into its effects on hearing.
- A systematic review of 1137 articles identified 18 studies showing a significant correlation between OSMF severity and hearing loss, particularly conductive hearing loss in advanced cases.
- The review highlighted that Eustachian tube dysfunction (ETD) often contributes to hearing issues in OSMF patients, emphasizing the importance of multidisciplinary management and early audiological screening for better patient outcomes.
Loss of Fascin2 increases susceptibility to cisplatin-induced hearing impairment and cochlear cell apoptosis in mice.
J Otol
July 2024
Department of Biochemistry and Molecular Biology, and Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, 346 Guanhai Road, Yantai, 264003, Shandong, PR China.
Objectives: Deletion of gene in mice has been linked to progressive hearing loss and degeneration of cochlear cells. Cisplatin, an antitumor drug, can cause various side effects, including ototoxicity. The aim of this study was to investigate the effects of on cisplatin-induced hearing impairment in mice and to explore the possible mechanism.
View Article and Find Full Text PDFInhibition of the cGAS‑STING Pathway Reduces Cisplatin-Induced Inner Ear Hair Cell Damage.
Neurosci Bull
December 2024
Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.
Although cisplatin is a widely used chemotherapeutic agent, it is severely toxic and causes irreversible hearing loss, restricting its application in clinical settings. This study aimed to determine the molecular mechanism underlying cisplatin-induced ototoxicity. Here, we established in vitro and in vivo ototoxicity models of cisplatin-induced hair cell loss, and our results showed that reducing STING levels decreased inflammatory factor expression and hair cell death.
View Article and Find Full Text PDFOtotoxic effects of unilateral postauricular neomycin administration on the inner ears of Guinea pigs.
Acta Otolaryngol
January 2025
Department of Otorhinolaryngology, Head and Neck Surgery, People's Hospital, Peking University, Beijing, PR China.
Backgrounds: Due to the therapeutic needs of inner ear diseases, a simple method of inner ear drug delivery has been under exploration. Postauricular administration, which involves injecting the drug through the middle of the retroauricular groove, is a potential novel approach, but its mechanisms remain unclear.
Objectives: To investigate threshold shifts in the auditory brainstem response (ABR), as well as the morphology and quantity of hair cells on the bilateral inner ear of guinea pigs after postauricular neomycin administration.
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