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Characterization of Effect of Enterovirus D68 in 129/Sv Mice Deficient in IFN-α/β and/or IFN-γ Receptors.
Comp Med
October 2024
1Department of Comparative Medicine, Stanford School of Medicine, Stanford, California.
Enterovirus D68 (EV-D68), a respiratory RNA virus in the family Picornaviridae, is implicated as a potential etiological agent for acute flaccid myelitis in preteen adolescents. The absence of a specific therapeutic intervention necessitates the development of an effective animal model for EV-D68. The AG129 mouse strain, characterized by the double knockout of IFN-α/β and IFN-γ receptors on the 129 genetic background, has been proposed as a suitable model for EV-D68.
View Article and Find Full Text PDFClinical and Diagnostic Features of West Nile Virus Neuroinvasive Disease in New York City.
Pathogens
May 2024
Program in Neuroinfectious Diseases, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
West Nile virus (WNV) neuroinvasive disease (WNND) occurs in approximately 1 percent of WNV-infected patients and typically presents as encephalitis, meningitis, or acute flaccid paralysis (AFP). WNND remains a difficult inpatient diagnosis, creating significant challenges for prognostication and therapy selection. We characterized the clinical and diagnostic features of WNND cases at two major academic medical centers in New York City in routine clinical practice.
View Article and Find Full Text PDFA Case of Lethargy Followed by New Abnormal Movements in an Infant With a History of HSV Encephalitis.
Clin Pediatr (Phila)
October 2022
Department of Pediatrics, Division of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Pathological Characteristics of Echovirus 30 Infection in a Mouse Model.
J Virol
May 2022
Department of Medical Microbiology, Weifang Medical Universitygrid.268079.2, Weifang, People's Republic of China.
Echovirus 30 (E30), a member of species B enterovirus, is associated with outbreaks of aseptic meningitis and has become a global health emergency. However, the pathogenesis of E30 remains poorly understood due to the lack of appropriate animal models. In this study, we established a mouse infection model to explore the pathogenicity of E30.
View Article and Find Full Text PDFHemorrhagic Meningoencephalomyelitis Due to Ectopic Localization of in a Cat: First Case Report.
Animals (Basel)
January 2022
Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.
The lungworm is one of the main causes of respiratory diseases in cats worldwide. This report describes the unusual case of a kitten infected with and presented to a veterinary clinic in Brazil with lethargy, dysphagia, non-ambulatory tetraplegia, and pelvic limbs bilateral myoclonus. The clinical picture of the kitten worsened with generalized flaccid tetraplegia and death a few days after hospitalization.
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