We have developed a route for the synthesis of 2'-selenium uridine analogues and oligonucleotides containing selenium labels, and have demonstrated for the first time a new strategy to covalently derivatize nucleotides with selenium for phase and structure determination in X-ray crystallography.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja0171097 | DOI Listing |
Publication Analysis
Top Keywords
oligonucleotides selenium
8
x-ray crystallography
8
internal derivatization
4
derivatization oligonucleotides
4
selenium x-ray
4
crystallography mad
4
mad developed
4
developed route
4
route synthesis
4
synthesis 2'-selenium
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!