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Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare.
ALTEX
January 2025
F. Hoffmann-La Roche Ltd, Precision Safety, Product Development, Basel, Switzerland.
The regular workshops held by the Center for Alternatives to Animal Testing (CAAT) on biology-inspired microphysiological systems (MPS) taking place every four years, have become a reliable measure to assess fundamental scientific, industrial and regulatory trends for translational science in the MPS-field from a bird's eye view. The 2023 workshop participants at that time concluded that the technology as used within academia has matured significantly, underlined by the broad use of MPS and the steadily increasing number of high quality research publications - yet, broad industry adoption of MPS has been slow, despite strong interest. Academic research using MPS primarily aims to accurately recapitulate human biology in MPS-based organ models in areas where traditional models have been lacking key elements of human physiology, thereby enabling breakthrough discoveries for life sciences.
View Article and Find Full Text PDFDispensing practices of amoxicillin suspension by community pharmacists.
Antimicrob Steward Healthc Epidemiol
September 2024
Emory University and Children's Healthcare of Atlanta, Atlanta, Georgia.
Background: Amoxicillin suspension is frequently prescribed to children; we hypothesized that prescribing convention system constraints lead to unusual dosing regimens and unnecessary waste of the drug.
Objective: Identify antibiotic dispensing practices by community pharmacists and/or technicians to understand opportunities to decrease wasted amoxicillin liquid and optimize prescribing convention of liquid amoxicillin to children.
Methods: Pilot online survey of Atlanta area and National Community Pharmacists Association pharmacists or pharmacy technicians that self-reported dispensing amoxicillin suspension.
Evaluating concerns for perampanel in the treatment of pediatric Dravet syndrome.
Transl Pediatr
December 2024
Karachi Medical and Dental College, Karachi, Pakistan.
Self-reported experiences and perspectives on using psychedelics to manage opioid use among participants of two Reddit communities.
Addiction
January 2025
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
Background And Aims: The opioid crisis continues to exert a tremendous toll in North America, with existing interventions often falling short of addressing ongoing needs. Psychedelics are emerging as a possible alternative therapy for mental health and substance use disorders. This study aimed to gather insights on how people use or are considering using psychedelics to manage opioid use disorder (OUD), how these experiences are perceived to impact opioid use and what these lessons imply for future research and practice.
View Article and Find Full Text PDFImproving breast cancer treatments using pharmacomicrobiomics.
mBio
January 2025
Center for Gastrointestinal Biology and Disease and Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Tamoxifen is the mainstay treatment for estrogen-positive breast cancer for over half a century. However, a significant proportion of patients experience disease recurrence due to treatment failure attributed to various factors, including disease pathology, genetics, and drug metabolism. Alam et al.
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