Detailed knowledge of the characteristics of the radiation field shaped by a multileaf collimator (MLC) is essential in intensity modulated radiotherapy (IMRT). A previously developed multiple source model (MSM) for a 6 MV beam was extended to a 15 MV beam and supplemented with an accurate model of an 80-leaf dynamic MLC. Using the supplemented MSM and the MC code GEANT, lateral dose distributions were calculated in a water phantom and a portal water phantom. A field which is normally used for the validation of the step and shoot technique and a field from a realistic IMRT treatment plan delivered with dynamic MLC are investigated. To assess possible spectral changes caused by the modulation of beam intensity by an MLC, the energy spectra in five portal planes were calculated for moving slits of different widths. The extension of the MSM to 15 MV was validated by analysing energy fluences, depth doses and dose profiles. In addition, the MC-calculated primary energy spectrum was verified with an energy spectrum which was reconstructed from transmission measurements. MC-calculated dose profiles using the MSM for the step and shoot case and for the dynamic MLC case are in very good agreement with the measured data from film dosimetry. The investigation of a 13 cm wide field shows an increase in mean photon energy of up to 16% for the 0.25 cm slit compared to the open beam for 6 MV and of up to 6% for 15 MV, respectively. In conclusion, the MSM supplemented with the dynamic MLC has proven to be a powerful tool for investigational and benchmarking purposes or even for dose calculations in IMRT.
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http://dx.doi.org/10.1088/0031-9155/46/12/312 | DOI Listing |
Med Phys
January 2025
Department of Medical Physics, Nova Scotia Health, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada.
intra-arc binary collimation (iABC) is a novel treatment technique in which dynamic conformal arcs are periodically interrupted with binary collimation. It has demonstrated its utility through planning studies for the treatment of multiple metastases. However, the binary collimation approach is idealized in the planning system, while the treatment deliveries must adhere to the physical limitations of the mechanical systems involved [e.
View Article and Find Full Text PDFRep Pract Oncol Radiother
December 2024
Department of Radiation Oncology, Kagawa University Hospital, Kagawa, Japan.
Nanotechnology
January 2025
Chinese Academy of Sciences, Institute of Microelectronics, No.3, Beitucheng West Road, Chaoyang District, beijing, 100029, CHINA.
In this letter, we investigated the impact of percolation transport mechanisms on ferroelectric field effect transistor (FeFET) multi-value storage with Kinetic Monte-Carlo (KMC) simulation considering aspect ratio and temperature dependencies. It is found that the portion of the ferroelectric polarization, which dominated the threshold voltage shift of the FeFET, increases when aspect ratio of device decreases. Moreover, randomness of percolation path formation and variations of equivalent conductance can be suppressed, indicating mitigation of device-to-device variations and enhancement of separation of individual states.
View Article and Find Full Text PDFTransl Oncol
January 2025
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China. Electronic address:
Ovarian cancer is a prevalent malignancy among women, often associated with a poor prognosis. Post-translational modifications (PTMs), particularly O-GlcNAcylation, have been implicated in the progression of ovarian cancer. Emerging evidence indicates that dysregulation of O-GlcNAcylation contributes to the initiation and malignant progression of ovarian cancer.
View Article and Find Full Text PDFMed Phys
January 2025
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: The multi-leaf collimator (MLC) is an advanced device utilized for beam shaping and intensity modulation in radiotherapy. With the framework of the contemporary single-layer MLC featuring a rounded leaf tip, the leaf tip transmission and leakage exert a considerable influence on radiotherapy.
Purpose: To scale down the leakage and transmission from the leaf gap when the opposite leaves are closed.
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