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GlnA3 is able to glutamylate spermine but it is not essential for the detoxification of spermine in .
J Bacteriol
January 2025
Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Department of Microbiology and Biotechnology, University of Tübingen, Tübingen, Baden-Württemberg, Germany.
Unlabelled: is well adapted to survive and persist in the infected host, escaping the host's immune response. Since polyamines such as spermine, which are synthesized by infected macrophages, are able to inhibit the growth of , the pathogen needs strategies to cope with these toxic metabolites. The actinomycete , a close relative of makes use of a gamma-glutamylation pathway to functionally neutralize spermine.
View Article and Find Full Text PDFAn analysis of knowledge, attitudes, practice and influencing factors for tuberculosis prevention and control among Hainan University students.
Front Public Health
January 2025
Department of Scientific Research, Hainan General Hospital, Haikou, China.
Objective: To assess the current status of knowledge, attitude, and practice pertaining to tuberculosis prevention among college students in Hainan Province, China, and to identify influential factors. The findings of this study are intended to provide valuable insights for the development and implementation of effective health education programs aimed at tuberculosis prevention and control.
Methods: A convenient sampling method was employed to conduct a questionnaire-based survey among college students at a university in Hainan Province using the Wenjuanxing platform from January to February 2023.
Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides.
Nat Commun
January 2025
Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, Japan.
Commensal bacteria affect host health by producing various metabolites from dietary carbohydrates via bacterial glycometabolism; however, the underlying mechanism of action remains unclear. Here, we identified Streptococcus salivarius as a unique anti-obesity commensal bacterium. We found that S.
View Article and Find Full Text PDFBackground Tuberculosis (TB) remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the infection. Bacterial persistence during exposure to bactericidal antibiotics is at least partially mediated by the bacterial stringent response enzyme, Rel .
View Article and Find Full Text PDFComprehensive analysis of vaginal microbiota in Chinese women with genital tuberculosis: implications for diagnosis and treatment.
BMC Microbiol
January 2025
The Gynecology Department of Beijing Obstetrics and Gynecology Hospital, Beijing Maternal and Child Health Care Hospital, Capital Medical University, No.251 of Yaojiayuan Road, Chaoyang district, Beijing, China.
Background: Tuberculosis remains an infectious disease of global concern, with potential impacts on respiratory and intestinal microbiota owing to prolonged broad-spectrum antibiotic therapy. Despite its potential to cause infertility, the vaginal microbiota of women with genital tuberculosis remains poorly understood. We comprehensively analyzed the vaginal microbiota in Chinese women with genital tuberculosis.
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