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Familial Reactive Perforating Collagenosis with Adolescence-Onset: A Rare Case Report and Literature Review.
Clin Cosmet Investig Dermatol
August 2024
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.
Article Synopsis
- - Familial Reactive Perforating Collagenosis (FRPC) is a rare, benign skin condition primarily seen in young children, with fewer than 50 documented cases, and its causes and treatments remain unclear.
- - A case study of a 20-year-old male from Indonesia showed multiple skin papules across his body for over 7 years, and similar symptoms were present in his family.
- - The patient was successfully treated with a topical corticosteroid, desoximetasone, leading to significant improvement in skin lesions, suggesting corticosteroids could be a viable treatment for FRPC.
Observing bioorthogonal macrocyclizations in the nuclear envelope of live cells using on/on fluorescence lifetime microscopy.
Chem Sci
August 2024
Department of Chemistry, RCSI Dublin 2 Ireland
The reactive partnership between azides and strained alkynes is at the forefront of bioorthogonal reactions, with their cellular studies often achieved through the use of off to on fluorophores with fluorescence microscopy. In this work, the first demonstration of a bioorthogonal, macrocycle-forming reaction occurring within the nuclear envelope of live cells has been accomplished, utilising on/on fluorescence lifetime imaging microscopy for real-time continuous observation of the transformation. The fluorescent, macrocyclic BF azadipyrromethene was accessible through a double 1,3-dipolar cycloaddition within minutes, between a precursor bis-azido substituted fluorophore and Sondheimer diyne in water or organic solvents.
View Article and Find Full Text PDFUnveiling the antifungal mechanisms of CTP, a new copper(II)-theophylline/1,10-phenanthroline complex, on drug-resistant non-albicans Candida species.
Biometals
October 2024
Laboratório de Estudos Avançados de Microrganismos Emergentes E Resistentes (LEAMER), Departamento de Microbiologia Geral, Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal Do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, 21941-902, Brazil.
Article Synopsis
- Candida species, especially Candida albicans, are the most common fungal pathogens in humans, but there’s been a rise in non-albicans Candida species (NACs) which show increased antifungal resistance.
- Recent research on a copper(II) coordination compound known as CTP has revealed its ability to effectively target and damage antifungal-resistant NACs by affecting their mitochondrial function and causing significant surface alterations.
- CTP not only inhibits biofilm formation by these invasive species but also disrupts established biofilms, making it a promising candidate for developing new antifungal treatments.
Case Report: An unusual case of wide ileoileal intussusception associated with intestinal volvulus in a 8-months-old infant.
Front Pediatr
February 2024
Department of General Surgery, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Article Synopsis
- Midgut volvulus and intussusception are common emergency conditions in children, and this is the first case reported linking the two.
- An 8-month-old boy presented to the emergency room with abdominal pain and vomiting, where physical exams and lab results indicated serious intestinal issues, including a hard mass and signs of inflammation.
- During surgery, doctors found a twisted intestinal loop that led to both volvulus and extensive intussusception, resulting in the resection of a significant portion of the ileum.
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