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Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2004
Departments of Medicine and Pharmacology, Vanderbilt University, 526 RBB, Nashville, TN 37232, USA.
Lipid peroxidation has been implicated in the pathophysiological sequelae of human neurodegenerative disorders. It is recognized that quantification of lipid peroxidation is best assessed in vivo by measuring a series of prostaglandin (PG) F2-like compounds termed F2-isoprostanes (IsoPs) in tissues in which arachidonic acid is abundant. Unlike other organs, the major polyunsaturated fatty acid (PUFA) in the brain is docosahexaenoic acid (DHA, C22:6 omega-6), and this fatty acid is particularly enriched in neurons.
View Article and Find Full Text PDFQuantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease.
Adv Exp Med Biol
July 2002
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Brain regional quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease.
Am J Pathol
January 2001
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Isoprostanes (IsoP) are produced exclusively from free radical damage to arachidonic acid, a fatty acid that is evenly distributed throughout white matter and gray matter, whereas neuroprostanes (NPs) are generated analogously from docosahexaenoic acid (DHA), a fatty acid enriched in gray matter where it is concentrated in neurons. IsoP and NPs derive from endoperoxide intermediates that isomerize to D/E-ring forms or that are reduced to F-ring compounds. We quantified F-ring and D/E-ring IsoP and NPs in temporal and parietal cortex, hippocampus, and cerebellum of nine definite Alzheimer's disease (AD) patients and 11 age-matched controls.
View Article and Find Full Text PDFQuantification of the major urinary metabolite of 15-F2t-isoprostane (8-iso-PGF2alpha) by a stable isotope dilution mass spectrometric assay.
Anal Biochem
May 1999
Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, Tennessee 37232, USA.
The isoprostanes (IsoPs) are a series of novel prostaglandin (PG)-like compounds generated from the free radical-catalyzed peroxidation of arachidonic acid. The first series of IsoPs characterized contained F-type prostane rings analogous to PGF2alpha. One F-ring IsoP, 15-F2t-IsoP (8-iso-PGF2alpha) has been shown to be formed in abundance in vivo and to exert potent biological activity.
View Article and Find Full Text PDFIdentification of non-cyclooxygenase-derived prostanoid (F2-isoprostane) metabolites in human urine and plasma.
J Biol Chem
February 1993
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-6602.
Free radicals are thought to play an important role in many types of tissue injury. Recently, we reported that a series of prostaglandin F2-like compounds (F2-isoprostanes) capable of exerting potent biological activity are produced in vivo by free radical-induced lipid peroxidation. Their formation is independent of the cyclooxygenase enzyme and has been shown to increase profoundly in animal models of free radical injury and lipid peroxidation.
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