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Biochemical biomarkers for the toxicity induced by traditional Chinese medicine: a review update.
J Ethnopharmacol
January 2025
The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:
Ethnopharmacological Relevance: Traditional Chinese medicine (TCM) is widely used in China for disease treatment and has become a valuable resource for drug development due to its high efficacy and low risk of side-effects. However, growing toxicity reports has garnered significant global attention. A major challenge in addressing TCM-induced toxicity is lack of specific and sensitive biomarkers for diagnosing and predicting its toxicity.
View Article and Find Full Text PDFTransformation mechanism, kinetics and ecotoxicity of kaempferol and quercetin in the gaseous and aqueous phases: A theoretical combined experimental study.
Sci Total Environ
January 2025
Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, China; State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Chang Ping, Beijing 102249, China.
The transformation and risk assessment of flavonoids triggered by free radicals deserve extensive attention. In this work, the degradation mechanisms, kinetics, and ecotoxicity of kaempferol and quercetin mediated by ∙OH, ∙OCH, ∙OOH, and O in gaseous and aqueous environments were investigated using cell experiments and quantum chemical calculations. Three radical scavenging mechanisms, including hydrogen atom transfer (HAT), radical adduct formation (RAF) and single electron transfer (SET) were discussed.
View Article and Find Full Text PDFA Faster Walking Speed Is Important for Improving Biomechanical Function and Walking Performance.
J Appl Biomech
January 2025
Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom.
This study compares joint kinematics and kinetics of young stroke survivors who walk <0.79 m/s (slow) or >0.80 m/s (fast) with reference to a healthy able-bodied group and provides clinical recommendations for guiding the gait rehabilitation of stroke survivors.
View Article and Find Full Text PDFSynthesis of -dA Damaged DNAs to Probe the Replication Ability of Human Translesion Polymerases.
J Org Chem
January 2025
Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
The DNA adducts formed by the alkenylbenzene natural products, safrole (SF) and methyleugenol (MEG) are primarily attributed to their reported carcinogenic properties. Herein, we report a concise strategy to access -Ac-SF/MEG-dA phosphoramidites, which were selectively incorporated into DNA oligonucleotides by solid-phase DNA synthesis. The replication studies using human polymerases hpolκ and hpolη showed that both polymerases replicate these adducts error-free, which indicates that these polymerases do not contribute to the adduct-induced mutagenicity.
View Article and Find Full Text PDFDihydrolevoglucosenone (CyreneTM) as a Bio-derived Liquid Organic Hydrogen Carrier.
Chempluschem
January 2025
Tohoku University, Institute of Multidisciplinary Research for Advanced Materials, 2-1-1 Katahira, Aoba-ku, 9808577, Sendai, JAPAN.
Organic hydrides can store hydrogen via chemical bonding under ambient conditions, enabling the safe storage and transportation of hydrogen gas using the same infrastructure for gasoline. However, in previous research, most organic hydrides have been produced from petroleum, and therefore replacing them with earth-abundant or renewable compounds is essential to ensure sustainability. This study demonstrates dihydrolevoglucosenone (CyreneTM), which is a biodegradable liquid ketone that is produced directly from biomass without pretreatments on an industrial scale, as a new renewable organic hydride.
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