The body surface distribution of the cardiac electric field is best represented as reliefs of positive and negative potentials, or their time integrals. The objective of this study was to design a methodology of their quantitative evaluation. QRST isointegral maps were obtained from 45 healthy subjects (35 men, 10 women, aged 10-67 years) using a 80 electrode set. Relative frequencies of positivity and of negativity were ascertained for different levels of the QRST integral values. Two fuzzy subsets: that of positive and that of negative QRST values were defined on the set of electrode placements. The values of membership functions of their elements were derived from relative frequencies obtained in the reference group of subjects, separately for all levels of QRST integral values. Statistics of these values characterize the reference reliefs of the positive and of the negative QRST values and are used to test their resemblance to a given individual distribution. In conclusion, the representation of isopotential, or isointegral body surface potential maps as reliefs of their positive and negative values, based on the theory of fuzzy sets, enables a quantitative evaluation of their resemblance to a given individual distribution. (Fig. 6, Ref. 18.)
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J Cancer Res Ther
December 2024
Department of Interventional Ultrasound, Fifth Center of Chinese People's Liberation Army General Hospital, Beijing, China.
Objective: To examine the diagnostic efficacy of contrast-enhanced ultrasound (CEUS) with Sonazoid (Sonazoid-CEUS) for endometrial lesions.
Methods: In this prospective and multicenter study, data were collected from 84 patients with endometrial lesions from 11 hospitals in China. All the patients received a conventional US and Sonazoid-CEUS examination.
Ophthalmol Ther
January 2025
International Health Policy Program (IHPP), Ministry of Public Health, Nonthaburi, Thailand.
Introduction: Screening diabetic retinopathy (DR) for timely management can reduce global blindness. Many existing DR screening programs worldwide are non-digital, standalone, and deployed with grading retinal photographs by trained personnel. To integrate the screening programs, with or without artificial intelligence (AI), into hospital information systems to improve their effectiveness, the non-digital workflow must be transformed into digital.
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January 2025
Department of General Surgery, Sir Run Run Hospital of Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 (NDUFA4L2) protein is located in the mitochondria and can regulate cell proliferation. Some studies have shown that the high NDUFA4L2 expression is linked with poor prognosis and cancer progression in various patients with cancers. However, the correlation between NDUFA4L2 and pan-cancer is unknown.
View Article and Find Full Text PDFStrahlenther Onkol
January 2025
Department of Radiology, Samut Sakhon Hospital, 74000, Samut Sakhon, Thailand.
Objective: This study aimed to evaluate the correlations between complete blood count (CBC) during radiotherapy and patient and treatment factors.
Patients And Methods: Data of cancer patients, including age, sex, concurrent chemotherapy (CCRT), radiotherapy dose (equivalent dose in 2‑Gy fractions with an alpha/beta value of 10 Gy, EQD2Gy10), radiotherapy location, and baseline CBC were collected. Linear regression was used to determine results during radiation.
Elife
January 2025
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United States.
The central amygdala (CeA) has emerged as an important brain region for regulating both negative (fear and anxiety) and positive (reward) affective behaviors. The CeA has been proposed to encode affective information in the form of valence (whether the stimulus is good or bad) or salience (how significant is the stimulus), but the extent to which these two types of stimulus representation occur in the CeA is not known. Here, we used single cell calcium imaging in mice during appetitive and aversive conditioning and found that majority of CeA neurons (~65%) encode the valence of the unconditioned stimulus (US) with a smaller subset of cells (~15%) encoding the salience of the US.
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