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Exploring the Potential Use of Withania somnifera in Leprosy and Lepra Reactions: A Molecular Docking Approach.
Infect Disord Drug Targets
December 2024
School of Information Technology, SRM University, Sikkim, India.
Introduction: Withania somnifera (Ashwagandha) is a traditional herb that is cur-rently commercially available for treating a variety of illnesses. By evaluating and verifying docking affinity scores, it is possible to explore the potential of the plant for treating leprosy and lepra-reaction as off-label use.
Methods: The sitoindosides were used as ligands along with thalidomide in docking against targets, such as M.
Tofacitinib in Leprosy: A Novel Therapeutic Approach in Chronic Recalcitrant Type II Reactions.
Cureus
November 2024
Dermatology, The Oxford Medical College, Hospital, and Research Centre, Bangalore, IND.
Leprosy is a chronic, infectious, and debilitating disorder that primarily affects the skin and peripheral nerves. The disease course may be complicated by immune-mediated reactions during or after therapy, which may further worsen nerve damage. Type II lepra reaction (T2LR) is a painful inflammatory condition with systemic features, such as fever, tender erythematous nodules, arthritis, neuritis, orchitis, lymphadenitis, and iritis.
View Article and Find Full Text PDFBridging dermatology and hematology: a case of lepromatous leprosy with bone marrow involvement and pancytopenia.
J Hematop
December 2024
Department of Haematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Leprosy, caused by Mycobacterium leprae (M. leprae), primarily manifests with cutaneous and peripheral nerve involvement. Systemic involvement, particularly in the bone marrow, is exceedingly rare.
View Article and Find Full Text PDFThe effect of antireaction medications on the association between periodontitis and leprosy reactions: An important methodological issue in periodontal medicine.
J Periodontol
June 2024
Department of Health, Feira de Santana State University, Feira de Santana, Bahia, Brazil.
Background: The treatment of leprosy reactions (LRs) involves thalidomide, corticosteroids, and other immunomodulatory medications. This study evaluated the effect of these treatments on the association between periodontitis and LRs, as well as factors associated with LRs.
Methods: This case-control study was conducted on 283 individuals followed at a leprosy outpatient clinic in Brazil.
A case report and literature review: Mycobacterium leprae infection diagnosed by metagenomic next-generation sequencing of cerebrospinal fluid.
BMC Infect Dis
July 2024
Center of Infectious Diseases, West China Hospital, Sichuan University, 37 Guoxue Lane, Chengdu, 610041, China.
Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae) that is responsible for deformities and irreversible peripheral nerve damage and has a broad spectrum of clinical and serological manifestations. Leprosy primarily affects the peripheral nerves and rarely presents with central nervous system involvement.
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