AI Article Synopsis
- Estrogen receptors ERalpha and ERbeta are crucial for estrogen action and impact various physiological functions beyond reproduction.
- Research using both in vivo and in vitro studies shows that these receptors are involved in endocrine-related diseases.
- Recent findings from studies on estrogen receptor knockout mice provide insights into their roles in brain degeneration, osteoporosis, cardiovascular diseases, and obesity.
Article Abstract
The estrogen receptors ERalpha and ERbeta are the main mediators of estrogen action and estrogens play an important role in a variety of aspects of physiology besides their well acknowledged function in reproduction. In vivo and in vitro studies indicate that the estrogen receptors are mechanistically implicated in endocrine-related diseases. Recent studies with estrogen receptor knockout mice have helped to unravel the role of the estrogen receptors in brain degeneration, osteoporosis, cardiovascular diseases and obesity.
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| http://dx.doi.org/10.1016/s1471-4892(01)00105-9 | DOI Listing |
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