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Identification and Evaluation of Natural Compounds as Potential Inhibitors of NS2B-NS3 Zika Virus Protease: A Computational Approach.
Mol Biotechnol
December 2024
Unit of Scientific Research, Applied College, Qassim University, Buraydah, 52571, Saudi Arabia.
The Zika virus (ZIKV), an arbovirus within the Flavivirus genus, is associated with severe neurological complications, including Guillain-Barré syndrome in affected individuals and microcephaly in infants born to infected mothers. With no approved vaccines or antiviral treatments available, there is an urgent need for effective therapeutic options. This study aimed to identify new natural compounds with inhibitory potential against the NS2B-NS3 protease (PDB ID: 5LC0), an essential enzyme in viral replication.
View Article and Find Full Text PDFTuberculosis Preventive Treatment in High TB-Burden Settings: A State-of-the-Art Review.
Drugs
December 2024
The Aurum Institute, Parktown, South Africa.
Tuberculosis (TB) is the leading cause of death from a single infectious agent. The burden is highest in some low- and middle-income countries. One-quarter of the world's population is estimated to have been infected with TB, which is the seedbed for progressing from TB infection to the deadly and contagious disease itself.
View Article and Find Full Text PDFEco-friendly cellulose paper composites: A sustainable solution for EMI shielding and green engineering applications.
Int J Biol Macromol
December 2024
International and Inter-University Centre for Nanoscience and Nanotechnology (IIUCNN), Mahatma Gandhi University, Kottayam, Kerala 686 560, India; School of Energy Materials, Mahatma Gandhi University, Kottayam, Kerala 686560, India; School of Nanoscience and Nanotechnology, Mahatma Gandhi University, Kottayam, Kerala 686560, India; Department of Chemical Sciences, University of Johannesburg, P.O.Box 17011, Doornfontein, 2028 Johannesburg, South Africa; Trivandrum Engineering, Science and Technology (TrEST) Research Park, Trivandrum 695016, India. Electronic address:
Cellulose paper-based composites represent a promising and sustainable alternative for electromagnetic interference (EMI) shielding applications. Derived from renewable and biodegradable cellulose fibers, these composites are enhanced with conductive fillers namely carbon nanotubes, graphene, or metallic nanoparticles, achieving efficient EMI shielding while maintaining environmental friendliness. Their lightweight, flexible nature, and mechanical robustness make them ideal for diverse applications, including wearable electronics, flexible circuits, and green electronics.
View Article and Find Full Text PDFAn overview of additive manufacturing strategies of enzyme-immobilized nanomaterials with application incatalysis and biomedicine.
Int J Biol Macromol
December 2024
School of Chemical Engineering, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, 280 Daehak-ro, Gyeongsan 38541, South Korea. Electronic address:
Meticulous and bespoke fabrication of structural materials with simple yet innovative outlines along with on-demand availability is the imperative aspiration for numerous fields. The alliance between nanotechnology and enzymes has led to the establishment of an inimitable and proficient class of materials. With the advancement in the field of additive manufacturing, the fabrication of some complex biological architects is achievable with similitude to the instinctive microenvironment of the biological tissue.
View Article and Find Full Text PDFProgress on HIV and other sexually transmitted infections elimination among youth and adults across BRICS-plus countries: Results from the Global Burden of Disease Study 2021.
J Infect Public Health
December 2024
Department of Global Health, School of Public Health, Peking University, Beijing 100191, China; Institute for Global Health and Development, Peking University, Beijing 100191, China. Electronic address:
Background: Global strategies aim to eradicate HIV and other sexually transmitted infections (STIs) by 2030. We aim to assess HIV and other STIs morbidity trends from 1992 to 2021 across BRICS-plus (Brazil, Russia, India, China, South Africa, Egypt, Ethiopia, Iran, Saudi Arabia, and the United Arab Emirates), which accounts for nearly half of the world population.
Methods: HIV and other STIs morbidity estimates were derived from the Global Burden of Disease Study 2021.
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