Based on changes of erythrocyte deformability (ED) found in normal pregnancy the authors decided to study the group of pregnant women with intrauterine fetal hypoxy. We selected 47 pregnant patients between 32 and 37 weeks of pregnancy with intrauterine fetal hypoxy, which was diagnosed by Doppler umbilical cord artery blood flow measurement and/or by CTG signs of fetal hypoxy. The control group was composed of 26 healthy women in the third trimester of pregnancy with uncomplicated pregnancy and labor. ED was studied in the venous blood of pregnant women using method of colloid-osmotic hemolysis (Mirossay et al., Clin Haemorheol Microcircul, 1997). 21 newborns from the study group, treated for intrauterine fetal hypoxy, were born without symptoms of hypoxy (non verified hypoxy) and 26 newborns had a diagnosis of hypoxy, based on Apgar score, pH, base excess, bicarbonate and clinical symptoms (verified hypoxy). The entire group of 47 pregnant women with fetal hypoxy had significantly decreased ED. The changes of ED in the group with non verified hypoxy post partum were less pronounced comparing to the group with verified hypoxy. The pattern of these changes is similar to those observed one day prior to delivery in normal pregnancy. Pregnancy complicated by intrauterine fetal hypoxy is accompanied by statistically highly significant decrease of erythrocyte deformability. Interestingly similar changes can be observed in the late uncomplicated pregnancy prior to delivery.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism.
N Engl J Med
March 2019
From the Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden (L.M.P., T.H., F.A.K., M.V.H.), the Department of Internal Medicine, Haga Teaching Hospital (L.M.P., A.T.A.M.), and the Department of Internal Medicine, Haaglanden Medical Center (H.M.A.H.), the Department of Vascular Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam (I.M.B., S.M.), the Department of Internal Medicine, Flevo Hospital, Almere (I.M.B., M.W.), the Department of Internal Medicine, Gelre Hospital, Apeldoorn (T.B.), the Department of Pulmonology, Groene Hart Hospital, Gouda (Y.P.A.D.), the Department of Internal Medicine, Red Cross Hospital, Beverwijk (L.M.F.), the Department of Hematology, Erasmus University Medical Center, Rotterdam (M.J.H.A.K.), and the Department of Internal Medicine, University Medical Center Utrecht, Utrecht (M.N.), all of which are part of the Dutch Thrombosis Network (DTN) - all in the Netherlands; the Department of Internal Medicine and Chest Diseases, Brest Hospital Center, Groupe d'Etude de Thrombose de Bretagne Occidentale, University of Brest, EA 3878, CIC-INSERM 1412, University of Brest, Brest (C.T., F.C.), Service de médecine vasculaire et thérapeutique, Centre Hospitalier Universitaire (CHU) Saint Etienne, INSERM CIC-1408, INSERM Unité 1059, Equipe Dysfonction Vasculaire et Hémostase, Université Jean-Monnet, Saint Etienne (L.B.), the Department of Vascular Medicine, Sainte Musse Hospital, Toulon (A.E.), the Emergency Department, CHU Grenoble-Alpes, Hypoxy-Physiopathology laboratory HP2 INSERM 1042, Grenoble (M.M.), the Emergency Department, CHU d'Angers, UFR Santé, Université d'Angers, Institut Mitovasc, UMR CNRS 6015 UMR INSERM 1083, Angers (P.-M.R.), the Department of Pulmonary Disease and Intensive Care Unit, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Faculté de Médecine, Université Sorbonne Paris Cité, INSERM UMR S 1140, Paris (O.S.), and the Emergency Department, CHU de Clermont-Ferrand, Clermont-Ferrand (J.S.), all of which are part of the French Clinical Research Infrastructure Network-Investigation Network on Venous Thrombo-Embolism (F-CRIN INNOVTE Network, Saint Etienne) - all in France; and the School of Medicine, University College Dublin, and the Department of Haematology, Rotunda Hospital Dublin, INViTE Network, Dublin (F.N.A.).
Background: Pulmonary embolism is one of the leading causes of maternal death in the Western world. Because of the low specificity and sensitivity of the d-dimer test, all pregnant women with suspected pulmonary embolism undergo computed tomographic (CT) pulmonary angiography or ventilation-perfusion scanning, both of which involve radiation exposure to the mother and fetus. Whether a pregnancy-adapted algorithm could be used to safely avoid diagnostic imaging in pregnant women with suspected pulmonary embolism is unknown.
View Article and Find Full Text PDFWe have studied the course of early neonatal period in the newborns with delayed intrauterine development syndrome (DIUDS). Clinical neurological and electroencephalographic (EEG) studies of 208 neonates with DIUDS have been performed. Control group consisted of 234 newborns with normal height-weight values.
View Article and Find Full Text PDFChanges of erythrocyte deformability in pregnancy with intrauterine fetal hypoxy.
Early Pregnancy (Cherry Hill)
January 2001
1st Department of Gynaecology and Obstetrics, Medical Faculty, P.J. Safarik University, Kosice, Slovakia.
Based on changes of erythrocyte deformability (ED) found in normal pregnancy the authors decided to study the group of pregnant women with intrauterine fetal hypoxy. We selected 47 pregnant patients between 32 and 37 weeks of pregnancy with intrauterine fetal hypoxy, which was diagnosed by Doppler umbilical cord artery blood flow measurement and/or by CTG signs of fetal hypoxy. The control group was composed of 26 healthy women in the third trimester of pregnancy with uncomplicated pregnancy and labor.
View Article and Find Full Text PDF[Trauma in the last trimester of pregnancy].
Unfallchirurg
June 1996
Klinik und Poliklinik der Unfall-, Hand- und Wiederherstellungschirurgie, Universität zu Köln.
Although accidents during pregnancy are fairly rare, besides endangering the mother, they nearly always mean a vital threat to the fetus: lethality rates are up to 8% for the mother and up to 34% for the fetus. Besides depression of the circulatory system in the mother, coupled with fetal hypoxy, injury to the placenta and uterus is also possible. Moreover, the unborn child may be injured by direct trauma.
View Article and Find Full Text PDFEffects of cytidine diphosphate choline on rats with memory deficits.
Arzneimittelforschung
August 1993
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
The effects of cytidine diphosphate choline (CDP-choline, CAS 987-78-0) on learning and memory in rats with memory deficits were examined using behavioral methods of active avoidance with punishment reinforcement (shuttle-box), passive avoidance with punishment reinforcement (step-through and step-down), and active avoidance with positive (alimentary) reinforcement (staircase-maze). In the majority of experiments CDP-choline was applied orally at doses of 10-50 or 100 mg/kg daily for 7 days before the training session. The experiments were carried out on young-adult (aged 5 months) and old (aged 22 months) rats and on rats with a low capability for retention of learned behavior.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!