In vitro potentiation of antibiotic activities by a catecholate iron chelator against chloroquine-resistant Plasmodium falciparum.

Antimicrob Agents Chemother

Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Le Pharo, 13007 Marseille, France.

Published: January 2002

FR160, a catechol iron chelator, and tetracyclines or norfloxacin exert in vitro additive or synergistic activity against a chloroquine-resistant Plasmodium falciparum clone. FR160 shows antagonistic effects in association with macrolides, ofloxacin, and rifampin.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127010PMC
http://dx.doi.org/10.1128/AAC.46.1.225-228.2002DOI Listing

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