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Recent Developments in the Metal-Catalyzed Synthesis of Nitrogenous Heterocyclic Compounds.
Molecules
November 2024
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Article Synopsis
- Metal-catalyzed cyclization reactions are an effective way to create carbocyclic and heterocyclic compounds, benefiting from the ability of transition metal complexes to activate and modify organic materials.
- Recent advancements have focused on synthesizing nitrogen-containing heterocycles such as imidazoles and pyridines, which are important in natural product synthesis and pharmaceuticals.
- Ongoing innovations in catalytic systems and reaction conditions are enhancing the efficiency and scope of these reactions, contributing to the evolution of synthetic organic chemistry.
Thiol Ligand-Modified Au for Highly Efficient Electroreduction of Nitrate to Ammonia.
Precis Chem
March 2024
Hefei National Research Center for Physical Sciences at the Microscale, Key Laboratory of Strongly-Coupled Quantum Matter Physics of Chinese Academy of Sciences, Key Laboratory of Surface and Interface Chemistry and Energy Catalysis of Anhui Higher Education Institutes, Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Electroreduction of nitrate (NO ) to ammonia (NH) is an environmentally friendly route for NH production, serving as an appealing alternative to the Haber-Bosch process. Recently, various noble metal-based electrocatalysts have been reported for electroreduction of NO . However, the application of pure metal electrocatalysts is still limited by unsatisfactory performance, owing to the weak adsorption of nitrogen-containing intermediates on the surface of pure metal electrocatalysts.
View Article and Find Full Text PDFEnhancing the single-molecule magnetic performance of β-diketonate Dy(III) complexes by modulating the coordination microenvironment and magnetic interaction: from a mononuclear to a dinuclear structure.
Dalton Trans
October 2024
State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering, College of Chemistry and Chemical Engineering, Ningxia University, Yinchuan 750021, China.
Based on a β-diketonate ligand, a mononuclear Dy(III) complex, [Dy(dmpd)(bpy)] (1) (dmpd = 4,4-dimethyl-1-phenylpentane-1,3-dione, bpy = 2,2'-dipyridyl), of [DyNO] type has been synthesized with a capping nitrogen-containing coligand. Then, a dual capping coligand 2,2'-bipyrimidine (bmp) is introduced to be a bridge to link two β-diketonate-Dy(III) motifs, leading to a new dinuclear Dy(III) complex, [Dy(dmpd)(bmp)] (2). Dy(III) centers in both complexes feature an NO octacoordinated environment with an approximate square-antiprism geometry ().
View Article and Find Full Text PDFCobalt-catalysed desymmetrization of malononitriles via enantioselective borohydride reduction.
Nat Chem
November 2024
State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong, Hong Kong, China.
The high nitrogen content and diverse reactivity of malononitrile are widely harnessed to access nitrogen-rich fine chemicals. Although the facile substitutions of malononitrile can give structurally diverse quaternary carbons, their access to enantioenriched molecules, particularly chiral amines that are prevalent in bioactive compounds, remains rare. Here we report a cobalt-catalysed desymmetric reduction of disubstituted malononitriles to give highly functionalized β-quaternary amines.
View Article and Find Full Text PDFPeptides as modulators of FPPS enzyme: A multifaceted evaluation from the design to the mechanism of action.
Eur J Med Chem
December 2024
Department of Pharmacy, University of Naples Federico II, Via Domenico Montesano, 49, 80131, Naples, Italy. Electronic address:
Article Synopsis
- Bone diseases result from an imbalance in bone remodeling due to increased activity of osteoclasts and decreased activity of osteoblasts, and the mevalonate pathway (MVA) is essential for maintaining this equilibrium through the action of the enzyme FPPS.
- FDA-approved nitrogen-containing bisphosphonates (N-BPs) target FPPS, highlighting its importance in treating bone-related diseases, while recent research focuses on developing new FPPS inhibitors using a combination of computational modeling, biochemical assays, and biophysical techniques.
- The study demonstrates that newly designed peptides and phosphopeptides effectively inhibit FPPS, showcasing potential as anti-cancer agents by impacting the MVA pathway in murine colorectal cancer cells.
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