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| http://dx.doi.org/10.1136/bmj.4.5987.23 | DOI Listing |
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Nonopioid medications for managing opioid withdrawal in acute care settings: A scoping review.
Am J Health Syst Pharm
December 2024
Banner - University Medical Center, Tucson, AZ, USA.
Purpose: There are hospitalized patients with chronic opioid use who will experience signs and symptoms of opioid withdrawal who were not on medications for opioid use disorder (OUD) prior to admission, do not want to start or are unable to start medications for OUD during admission, and want to limit or avoid the use of opioids. The purpose of this scoping review was to assess the potential effectiveness and safety of using non-opioid agents for managing acute opioid withdrawal in acute care settings.
Methods: PubMed (inception to 2024), Embase (inception to 2024), and Cochrane Library (inception to 2024) were the databases evaluated for the literature search.
Personal Experiences With Xylazine and Behavior Change: A Qualitative Content Analysis of Reddit Posts.
J Addict Med
September 2024
From the Department of Child, Family, and Population Health Nursing, University of Washington School of Nursing, Seattle, WA (OH); Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (OKS, SG, VF, BKS); Department of Health Behavior and Society, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (AKW); Department of Biomedical Engineering, Johns Hopkins Medicine, Baltimore, MD (RR).
Objectives: Xylazine is a rapidly spreading adulterant in the United States' drug supply and is increasingly associated with overdoses and severe wounds, but there is a dearth of information about the clinical presentation or means of treatment for human xylazine exposure. The objective of this study was to explore personal attitudes about xylazine in the drug supply and experiences with xylazine-related use among people who reported using drugs and contributed content to social media site Reddit.
Methods: To conduct a retrospective qualitative content analysis, the study team extracted all posts and comments from Reddit, which mentioned the terms "xylazine" or "tranq.
A historical perspective on clonidine as an alpha-2A receptor agonist in the treatment of addictive behaviors: Focus on opioid dependence.
INNOSC Theranostics Pharmacol Sci
July 2024
Department of Psychiatry, Mt. Sinai School of Medicine, New York City, New York, United States of America.
Clonidine operates through agonism at the alpha-2A receptor, a specific subtype of the alpha-2-adrenergic receptor located predominantly in the prefrontal cortex. By inhibiting the release of norepinephrine, which is responsible for withdrawal symptoms, clonidine effectively addresses withdrawal-related conditions such as anxiety, hypertension, and tachycardia. The groundbreaking work by Gold .
View Article and Find Full Text PDFEvaluation of medications used for opioid use disorder in emergency departments: A cross-sectional analysis of the 2020 National Hospital Ambulatory Medical Care Survey.
Am J Emerg Med
August 2024
Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA. Electronic address:
Introduction: Opioid use disorder (OUD) is a significant health issue impacting millions in the United States (US). Medications used for OUD (MOUD) (e.g.
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